The activities of the group encompass different areas including, small heterocyclic chemistry, enabling technologies, flow chemistry, main groups organometallic chemistry (lithium, magnesium), sulfur, nitrogen, boron and fluorine chemistry and spectroscopic investigations.
Organic chemistry offers “plenty of opportunities to creativity”!!!
Chemistry of Small Heterocycles
The chemistry of strained three and four membered heterocycles such as aziridines, azetidines, oxazetidines, thietanes, and others is investigated.
The role of the ring substituents and dynamics, phenomena are exploited for a regio- ae chem-selective decoration.
Microreactor Technology and Flow-Chemistry
The use of flow technology as enabling technology allow for the development of synthetic processes that are difficult or "impossible" to realize with traditional batch chemistry.
Facilities in our flow chemistry lab "FLAME-Lab" are essential to accomplish this task.
Electrophilic Nitrogen Transfer
In collaboration with J. Bull at ICL we discovered a new stratgey for the introduction of an electrophilic nitrogen into a molecule.
The iodonitrene intermediates is opening up new possibilities in modern synthetic chemistry.
As a long lasting tradition, we have been involved in organolithium chemistry.
In particular, genesis, reactivity and stability of heterosubstituted organolithiums is investigated.
Recently, stimulated by a pharma company interested in the development of new molecular entities containing the fluorine atom, we embarked in the developement of new synthetic strategies of fluorinated molecules via organometallics bearing the fluorine and metal atoms on the same carbon.
Spectroscopic Investigations by NMR, HRMS, FT-IR
Understanding reaction mechanisms is at the "heart" of organic transformations. When a mechanism is deeply supported from experimental data, several breakthrough could be achieved and more reliable synthetic strategies can be developed.
We use modern spectroscopic techniques as tool for the identification of reactive intermediates and for clarify reaction mechanisms. FT-IR, HRMS and Multinuclear Magnetic Resonance are employed for this purpose.