RECENT PUBLICATIONS
2025-2026
Niamh Disney; Laura Marraffa; Mert Can Ince; Philipp Natho; Marco Colella; Gianvito Vilé; Marcus Baumann; and Renzo Luisi
A novel and sustainable continuous-flow approach for atom deletion and insertion by electrophilic nitrogen transfer
Green Chem. 2026, 28, 11000–11009.
https://doi.org/10.1039/d6gc01875k
Maria Chiara Cabua; Iktedar Mahdi; Ernesto Mesto; Emanuela Schingaro; Francesco Secci; Sehrish Sarfaraz; Marco Colella; Philipp Natho; Nadeem S. Sheikh and Renzo Luisi
Single-carbon insertion enables conversion of cyclopropenes into cyclobutenes: access to oxaspiro[2.3]hexenes
Chem. Sci. 2026
https://doi.org/10.1039/d6sc02968j
Philipp Natho, Annarita Vicenti, Fabrizio Mastrolorito, Francesca De Franco, Lee Walsh-Benn, Marco Colella, Ernesto Mesto, Emanuela Schingaro, Orazio Nicolotti, Antimo Gioiello, and Renzo Luisi
Novel Sulfonium Reagents for the Modular Synthesis of Spiro[2.3]Hexanes and Heteroatom-Containing Analogues: Synthesis, Application, and Evaluation as Bioisosteres
Angewandte Chemie - International Edition, 2026, 65(5), e21633 - https://doi.org/10.1002/anie.3488479
Philipp Natho, Annarita Vicenti, Marco Colella, Francesco Pasca, Giuseppe Romanazzi, Mauro Niso, Carmen Abate, Ernesto Mesto, Emanuela Schingaro, and Renzo Luisi
A Novel Class of “Super-Strained” Spiro Heterocycles: Gateway to 1-Azaspiro[3.3]heptane Derivatives, and Biological Validation
Angewandte Chemie - International Edition, 2026, e3488479 - https://doi.org/10.1002/anie.3488479
Theodore A. Gazis; Rodolfo I. Teixeira; Giulio Volpin; Ashish Yewale; Mert Can Ince; Mark J. Ford; Jan Harmsen; Marco Uboldi; Alice Melocchi; Mattia Sponchioni; Andrea Aramini; Renzo Luisi; Brahim Benyahia; Gianvito Vilé
Towards greener-by-design fine chemicals. Part 2: technological frontiers
Chemical Society Reviews, 2026, 55, 675–713
Theodore A. Gazis; Jonas Wuyts; Areti Moutsiou; Giulio Volpin; Mark J. Ford; Rodolfo I. Teixeira; Katherine M. P. Wheelhouse; Philipp Natho; Polona Žnidaršič-Plazl; Sonja Jost; Renzo Luisi; Brahim Benyahia; Bert U. W. Maes; Gianvito Vilé
Towards greener-by-design fine chemicals. Part 1: synthetic frontiers
Chemical Society Reviews, 2026, 55, 619–674
Gelato, Yuri, Natho, Philipp, Colella, Marco, and Renzo Luisi
Strain Release of 1-Azabicyclo[1.1.0]butanes as a Gateway to Highly Functionalized Azetidines: New Strategies and Structural Motifs
Chemistry - A European Journal, 2026 - https://doi.org/10.1002/chem.71087
Natho Philipp, Colella Marco, and Renzo Luisi
A Decade of NH-Transfer via Iodonitrene: A Journey of NH-Transfer from Sulfur and Nitrogen to Alkenes
Synlett, 2026, 1319 - 1324
Natho Philipp, Colella Marco, and Renzo Luisi
Flow Chemistry Applied for Late-Stage Functionalization and Other Functional Group-Tolerant Manipulation
Wiley Book; Late-Stage Functionalization and Diversification in Organic Synthesis: Methods and Applications, 2026, pp. 117–146
Yuri Gelato; Laura Marraffa; Francesco Pasca; Philipp Natho; Giuseppe Romanazzi; Arianna Tota; Marco Colella and Renzo Luisi
Iodonitrene-mediated synthesis of NH-aziridines
Trends in Chemistry, 2025, 7, 916–917
Serbetci, Defne; Natho, Philipp; Mesto, Ernesto; Schingaro, Emanuela; Colella, Marco and Renzo Luisi
Azabicyclo[1.1.0]butyl-Substituted Sulfonimidoyl Fluoride: Electrophilic Hub Bridging Late-Stage Azetidine Incorporation with Sufex Chemistry
Advanced Synthesis and Catalysis, 2025, 367, e70049
Giulia De Santis, Andrea Maranzana, Federica Lauria, Mauro Spennacchio, Michael Andresini, Rosa Purgatorio, Marco Colella, Renzo Luisi, Leonardo Degennaro
Tunable Preparation of α-Aminoacyl Fluorides and α-Fluoroamides via Base-Induced Cascade Multiple-Cleavage Processes from Bromodifluorohydrin Reagents and Amines
Advanced Synthesis and Catalysis, 2025, 367, e70083
Francesco Soddu; Iktedar Mahdi; Maria Chiara Cabua; Francesco Secci; Philipp Natho; Riccardo Tassoni; Paolo Dambruoso; Ernesto Mesto; Marco Colella; and Renzo Luisi
Generation and Use of Cyclopropenyllithium under Continuous Flow Conditions
Organic Letters, 2025, 27, 5754–5759
Natho Philipp, Colella Marco, and Renzo Luisi
Strained spiro heterocycles as potential bioisosteres: an update on the synthesis of heteroatom-containing spiro[2.3]hexanes and spiro[3.3]heptanes
Chemical Communications, 2025, 61, 6579–6594
Şerbetçi Defne, Marraffa, Laura, Natho, Philipp, Andresini, Michael, and Renzo Luisi
A Practical Guide to SuFEx Chemistry: An Overview of S(VI)-SuFEx Linkers and Their Reactivity
Synthesis, 2025, 57, 1569–1582
Graziano Elena, Colella Marco, Baumann Marcus,
and Renzo Luisi
Generation and Use of Bicyclo[1.1.0]butyllithium under Continuous Flow Conditions
Organic Letters, 2025, 27, 3344–3348
Michael Andresini, Laura Marraffa, Defne Şerbetçi, Philipp Natho, Marco Colella, Leonardo Degennaro, and Renzo Luisi
Synthesis of Aza-S(VI) Fluorides and Primary Sulfonimidamides from Sulfinylamines
Advanced Synthesis and Catalysis, 2025, 367, e202400908
Yuri Gelato; Laura Marraffa; Francesco Pasca; Philipp Natho; Giuseppe Romanazzi; Arianna Tota; Marco Colella and Renzo Luisi
Iodonitrene-Mediated Nitrogen Transfer to Alkenes for the Direct Synthesis of NH-Aziridines
Journal American Chemical Society 2025,147, 35567–35575
Philipp Natho, Marco Colella, Annarita Vicenti, Giuseppe Romanazzi, Faizan Ullah, Nadeem Sadiq Sheikh, Andrew J. P. White, Francesco Pasca, and Renzo Luisi
Shifting Lithium Amide Reactivity to the Radical Domain: Regioselective Radical C-H Functionalization of 3-Iodooxetane for the Synthesis of 1,5-Dioxaspiro[2.3]hexanes
Angew. Chem. Int. Ed. 2025, e202424346
Francesco Pasca, Yuri Gelato, Michael Andresini, Defne Serbetci, Philipp Natho, Giuseppe Romanazzi, Leonardo Degennaro, Marco Colella, Renzo Luisi
Continuous Flow Decarboxylative Monofluoroalkylation Enabled by Photoredox Catalysis
JACS Au, 2025 684–692.
2024
F. Pasca, Y. Gelato, M. Andresini, G. Romanazzi, L. Degennaro, M. Colella, R. Luisi;
Synthesis of alcohols: streamlined C1 to Cn hydroxyalkylation through photoredox catalysis
Chem. Sci., 2024, 15, 11337-11346
P. Natho, M. Colella, M. Andresini, L. Degennaro, R. Luisi
Taming 3-Oxetanyllithium Using Continuous Flow Technology
Org. Lett., 2024, 26, 3032-3036
E. Graziano, P. Natho, M. Andresini, F. Mastrolorito, I. Mahdi, E. Mesto, M. Colella, L. Degennaro, O. Nicolotti, R. Luisi
1-Oxa-2,6-Diazaspiro[3.3]heptane as a New Potential Piperazine Bioisostere – Flow-Assisted Preparation and Derivatisation by Strain-Release of Azabicyclo[1.1.0]butanes
Adv. Synth. Catal., 2024, 366, 3894-3902
R. I. Teixeira, M. Andresini, R. Luisi, B. Benyahia
Computer-Aided Retrosynthesis for Greener and Optimal Total Synthesis of a Helicase-Primase Inhibitor Active Pharmaceutical Ingredient
JACS Au, 2024, 4, 4263-4272
D. Serbetci, L. Marraffa, P. Natho, M. Andresini, R. Luisi
A Practical Guide to SuFEx Chemistry: An Overview of S(VI)-SuFEx Linkers and Their Reactivity,
Synthesis, 2024, 56, 10.1055/a-2410-2039
M. Andresini, L. Marraffa, D. Serbetci, P. Natho, M. Colella, L. Degennaro, R. Luisi
Synthesis of Aza-S(VI) Fluorides and Primary Sulfonimidamides from Sulfinylamines Adv. Synth. Catal., 2024, early view, 10.1002/adsc.202400908
Adv. Synth. Catal., 2024, early view, 10.1002/adsc.202400908
M. Andresini, M. Colella, L. Degennaro, R. Luisi
Overlooked aza-S(iv) motifs: synthesis and transformations of sulfinamidines and sulfinimidate esters
Org. Biomol. Chem., 2023, 21, 7681-7690
2023
M. Andresini, M. Colella, R. Savina Dibenedetto, E. Graziano, G. Romanazzi, A. Aramini, L. Degennaro, R. Luisi
Sustainable continuous flow synthesis of β-aminocarbonyls via acid-catalyzed hydration of N-Boc-2-azetines
React. Chem. Eng. 2023, 3203-3209
Colella M., Gelato Y., Andresini M., Graziano E., Vilé G., Degennaro L., Luisi R.
Forging C−S Bonds on the Azetidine Ring by Continuous Flow Photochemical Addition of Thiols and Disulfides to Azetines
European Journal of Organic Chemistry 2023
DOI: 10.1002/ejoc.202300413
P. Natho, R. Luisi
Flow chemistry as green technology for the genesis and use of organometallic reagents in the synthesis of key building blocks and APIs – an update
Tetrahedron Green Chem. 2023
DOI: 10.1016/j.tgchem.2023.100015
Gioiello A., Ceccarelli G., Colella M., Luisi R.
Streamlining C1 Homologation Reactions Using Continuous Flow Technology: Focus on Diazomethane and Methyllithium Chemistry
(2023) Homologation Reactions: Reagents, Applications, and Mechanisms: Volume 1 and 2, 1-2, pp. 143 - 190
DOI: 10.1002/9783527830237.ch3
Tota A., Spennacchio M., Briggs E.L., Ma T.-K., Zhong Z., Degennaro L., Bull J.A., Luisi R.
Synthesis of NH-Sulfoximines from Sulfides Using Ammonium Carbamate and (Diacetoxyiodo)benzene to Transfer NH and O
Organic Syntheses, 2023, 100, 48 - 60
DOI: 10.15227/orgsyn.100.0048
Briggs E.L., Ma T.-K., Zhong Z., Tota A., Degennaro L., Luisi R., Bull J.A.
Synthesis of Enantioenriched NH-Sulfoximines by NH Transfer to Sulfoxides Using Ammonium Carbamate and (Diacetoxyiodo)benzene
Organic Syntheses, 2023, 100, 186 - 198
DOI: 10.15227/orgsyn.100.0186
Luisi R., Bull J.A.
Synthesis of Sulfoximines and Sulfonimidamides Using Hypervalent Iodine Mediated NH Transfer
Molecules, 2023, 28 (3), 1120
DOI: 10.3390/molecules28031120
2022
Colella, M.; Musci, P.; Andresini, M.; Spennacchio, M.; Degennaro, L.; Luisi, R.
The synthetic versatility of fluoroiodomethane: recent applications as monofluoromethylation platform.
Organic & Biomolecular Chemistry 2022, 20 (23), 4669-4680
Andresini, M.; Carret, S.; Degennaro, L.; Ciriaco, F.; Poisson, J. F.; Luisi, R.
Multistep Continuous Flow Synthesis of Isolable NH2-Sulfinamidines via Nucleophilic Addition to Transient Sulfurdiimide.
Chemistry - A European Journal 2022, 28 (59)
Musci, P.; Colella, M.; Andresini, M.; Aramini, A.; Degennaro, L.; Luisi, R.
Flow technology-enabled preparation of C3-heterosubstituted 1-azabicyclo[1.1.0]butanes and azetidines: accessing unexplored chemical space in strained heterocyclic chemistry.
Chemical Communications 2022, 58 (43), 6356-6359
Spennacchio M., Colella M., Andresini M., Dibenedetto R.S., Graziano E., Aramini A., Degennaro L., Luisi R.
Unlocking geminal fluorohaloalkanes in nucleophilic fluoroalkylation chemistry: generation and trapping of lithiumfluorocarbenoids enabled by flow microreactors
ChemComm, 2022 59 (10), 1373 - 1376
DOI: 10.1039/d2cc06717j
Sivo A., Kim T.K., Ruta V., Luisi R., Osorio-Tejada J., Escriba-Gelonch M., Hessel V., Sponchioni M., Vilé G.
Enhanced flow synthesis of small molecules by in-line integration of sequential catalysis and benchtop twin-column continuous chromatography
React. Chem. Eng., 2022, 7 (12), 2650 - 2658
DOI: 10.1039/d2re00242f
Luisi R., Degennaro L., Colella M.
Lithium Complexes in Organic Synthesis
(2022) Comprehensive Organometallic Chemistry IV: Volume 1-15, 1-15, pp. 2 - 56
DOI: 10.1016/B978-0-12-820206-7.00049-4
Musci P., Colella M., Altomare A., Romanazzi G., Sheikh N.S., Degennaro L., Luisi R.
Dynamic Phenomena and Complexation Effects in the α-Lithiation and Asymmetric Functionalization of Azetidines
Molecules, 2022, 27 (9), 2847
DOI: 10.3390/molecules27092847
Tota A., Andresini M., Colella M., Dibenedetto R.S., Degennaro L., Luisi R.
(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl (R)-4-methylbenzenesulfonimidate
(2022) MolBank, 2022 (4), art. no. M1518
DOI: 10.3390/M1518
Urbonavičius A., Fortunato G., Ambrazaitytė E., Plytninkienė E., Bieliauskas A., Milišiūnaitė V., Luisi R., Arbačiauskienė E., Krikštolaitytė S., Šačkus A.
Synthesis and Characterization of Novel Heterocyclic Chalcones from 1-Phenyl-1H-pyrazol-3-ol
Molecules, 2022, 27 (12), 3752
DOI: 10.3390/molecules27123752
2021
P. Musci,T. von Keutz, F. Belaj,Prof. L. Degennaro, D. Cantillo, C. O. Kappe, R. Luisi
Flow Technology for Telescoped Generation, Lithiation and Electrophilic (C3) Functionalization of Highly Strained 1-Azabicyclo[1.1.0]butanes
Angew. Chem. Int. Ed. Engl. 2021, 60, 6395-6399
Andresini, M.; Spennacchio, M.; Colella, M.; Losito, G.; Aramini, A.; Degennaro, L.; Luisi, R.
Sulfinimidate Esters as an Electrophilic Sulfinimidoyl Motif Source: Synthesis of N-Protected Sulfilimines from Grignard Reagents.
Organic Letters 2021, 23 (17), 6850-6854.
M. Colella, P. Musci, D. Cannillo, M. Spennacchio, A. Aramini, L. Degennaro, R. Luisi
Development of a Continuous Flow Synthesis of 2-Substituted Azetines and 3-Substituted Azetidines by Using a Common Synthetic Precursor
J. Org. Chem. 2021, 86, 20, 13943–13954
Tota A., Colella M., Carlucci C., Aramini A., Clarkson G., Degennaro L., Bull J.A., Luisi R.
N−N Bond Formation Using an Iodonitrene as an Umpolung of Ammonia: Straightforward and Chemoselective Synthesis of Hydrazinium Salts
Adv. Syn. Cat., 2021, 363 (1), 194 - 199
DOI: 10.1002/adsc.202001047
Craven G.B., Briggs E.L., Zammit C.M., McDermott A., Greed S., Affron D.P., Leinfellner C., Cudmore H.R., Tweedy R.R., Luisi R., Bull J.A., Armstrong A.
Synthesis and Configurational Assignment of Vinyl Sulfoximines and Sulfonimidamides
J. Org. Chem., 2021, 86 (11), 7403 - 7424
DOI: 10.1021/acs.joc.1c00373
Andresini M., Degannaro L., Luisi R.
A sustainable strategy for the straightforward preparation of 2H-azirines and highly functionalized NH-aziridines from vinyl azides using a single solvent flow-batch approach
Beilstein Journal of Organic Chemistry, 2021 17, 203 - 209
DOI: 10.3762/BJOC.17.20
Cocco A., Rubanu M.G., Sechi M.L., Frongia A., Mastrorilli P., Degennaro L., Colella M., Luisi R., Secci F.
Lithiated three-membered heterocycles as chiral nucleophiles in the enantioselective synthesis of 1-oxaspiro[2,3]hexanes
Org. Biom. Chem., 2021, 19 (9), 1945 - 1949
DOI: 10.1039/d0ob00771d
M. Andresini, A. Tota, L. Degennaro, J. A. Bull, R. Luisi
Synthesis and Transformations of NH-Sulfoximines.
Chemistry - A European Journal 2021, 27, 17293-17321.
Andresini M., Degennaro L., Luisi R.
Azetidines, Azetines and Azetes: Monocyclic
(2021) Comprehensive Heterocyclic Chemistry IV, pp. 1 - 115
DOI: 10.1016/B978-0-12-818655-8.00155-4
Andresini M., Colella M., Degennaro L., Luisi R.
Hypervalent iodine (III) reagents and ammonia as useful combination for highly chemoselective N-transfer to low-valent organosulfur compounds and amines
(2021) Arkivoc, 2022 (4)
DOI: 10.24820/ark.5550190.p011.654