![](https://static.wixstatic.com/media/11062b_74ef3d923f9b451492d3ed9278991873f000.jpg/v1/fill/w_288,h_162,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/11062b_74ef3d923f9b451492d3ed9278991873f000.jpg)
RECENT PUBLICATIONS
2023
![React-Chem-Eng-Azetine-Opening.jpg](https://static.wixstatic.com/media/b824cb_3968520252434d3fb97a891856e69678~mv2.jpg/v1/fill/w_142,h_47,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/React-Chem-Eng-Azetine-Opening.jpg)
M. Andresini, M. Colella, R. Savina Dibenedetto, E. Graziano, G. Romanazzi, A. Aramini, L. Degennaro, R. Luisi
Sustainable continuous flow synthesis of β-aminocarbonyls via acid-catalyzed hydration of N-Boc-2-azetines
React. Chem. Eng. 2023, Just accepted
![EuJOC-Thiol-Azetine_edited.jpg](https://static.wixstatic.com/media/b824cb_5c6fd16f81fc4b489fb9a7ec55ad1f9b~mv2.jpg/v1/fill/w_107,h_56,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/EuJOC-Thiol-Azetine_edited.jpg)
Colella M., Gelato Y., Andresini M., Graziano E., Vilé G., Degennaro L., Luisi R.
Forging C−S Bonds on the Azetidine Ring by Continuous Flow Photochemical Addition of Thiols and Disulfides to Azetines
European Journal of Organic Chemistry 2023
DOI: 10.1002/ejoc.202300413
![Tet-Green-Chem-Review-Flow-Li_edited.jpg](https://static.wixstatic.com/media/b824cb_8153d186cd04499bb9bb6f3ee73fb95f~mv2.jpg/v1/fill/w_107,h_51,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/Tet-Green-Chem-Review-Flow-Li_edited.jpg)
P. Natho, R. Luisi
Flow chemistry as green technology for the genesis and use of organometallic reagents in the synthesis of key building blocks and APIs – an update
Tetrahedron Green Chem. 2023
DOI: 10.1016/j.tgchem.2023.100015
![Homologation-Chapter_edited.jpg](https://static.wixstatic.com/media/b824cb_81f21f6a589c4ffda8cd52ae6d2ef91a~mv2.jpg/v1/fill/w_107,h_84,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/Homologation-Chapter_edited.jpg)
Gioiello A., Ceccarelli G., Colella M., Luisi R.
Streamlining C1 Homologation Reactions Using Continuous Flow Technology: Focus on Diazomethane and Methyllithium Chemistry
(2023) Homologation Reactions: Reagents, Applications, and Mechanisms: Volume 1 and 2, 1-2, pp. 143 - 190
DOI: 10.1002/9783527830237.ch3
![Org-Synt-Sulfide.jpg](https://static.wixstatic.com/media/b824cb_fa8cc698fc5041b19c476abce35e0e3a~mv2.jpg/v1/fill/w_142,h_47,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/Org-Synt-Sulfide.jpg)
Tota A., Spennacchio M., Briggs E.L., Ma T.-K., Zhong Z., Degennaro L., Bull J.A., Luisi R.
Synthesis of NH-Sulfoximines from Sulfides Using Ammonium Carbamate and (Diacetoxyiodo)benzene to Transfer NH and O
Organic Syntheses, 2023, 100, 48 - 60
DOI: 10.15227/orgsyn.100.0048
![OrgSynth-Sulfoxide.jpg](https://static.wixstatic.com/media/b824cb_70f4154350204b8398f5c6adb2ef9e9a~mv2.jpg/v1/fill/w_142,h_47,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/OrgSynth-Sulfoxide.jpg)
Briggs E.L., Ma T.-K., Zhong Z., Tota A., Degennaro L., Luisi R., Bull J.A.
Synthesis of Enantioenriched NH-Sulfoximines by NH Transfer to Sulfoxides Using Ammonium Carbamate and (Diacetoxyiodo)benzene
Organic Syntheses, 2023, 100, 186 - 198
DOI: 10.15227/orgsyn.100.0186
![Molecules-Review-SUlfoximine.jpg](https://static.wixstatic.com/media/b824cb_27c46d25813b4ba3980a015f6e545aec~mv2.jpg/v1/fill/w_142,h_47,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/Molecules-Review-SUlfoximine.jpg)
Luisi R., Bull J.A.
Synthesis of Sulfoximines and Sulfonimidamides Using Hypervalent Iodine Mediated NH Transfer
Molecules, 2023, 28 (3), 1120
DOI: 10.3390/molecules28031120
2022
![Diapositiva11_edited.jpg](https://static.wixstatic.com/media/b824cb_d34e1f8189004243a5230567549c8845~mv2.jpg/v1/fill/w_108,h_53,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/Diapositiva11_edited.jpg)
Colella, M.; Musci, P.; Andresini, M.; Spennacchio, M.; Degennaro, L.; Luisi, R.
The synthetic versatility of fluoroiodomethane: recent applications as monofluoromethylation platform.
Organic & Biomolecular Chemistry 2022, 20 (23), 4669-4680
![Sulfinamidine-2022-Chem.jpg](https://static.wixstatic.com/media/b824cb_56deb0a06534408cb5f5e9133e728fa0~mv2.jpg/v1/fill/w_159,h_53,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/Sulfinamidine-2022-Chem.jpg)
Andresini, M.; Carret, S.; Degennaro, L.; Ciriaco, F.; Poisson, J. F.; Luisi, R.
Multistep Continuous Flow Synthesis of Isolable NH2-Sulfinamidines via Nucleophilic Addition to Transient Sulfurdiimide.
Chemistry - A European Journal 2022, 28 (59)
![Diapositiva10_edited.jpg](https://static.wixstatic.com/media/b824cb_7ada4d00dab545fb9e92a5ab585307a7~mv2.jpg/v1/fill/w_145,h_53,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/Diapositiva10_edited.jpg)
Musci, P.; Colella, M.; Andresini, M.; Aramini, A.; Degennaro, L.; Luisi, R.
Flow technology-enabled preparation of C3-heterosubstituted 1-azabicyclo[1.1.0]butanes and azetidines: accessing unexplored chemical space in strained heterocyclic chemistry.
Chemical Communications 2022, 58 (43), 6356-6359
![ChemComm-Fluoro-Li_edited.jpg](https://static.wixstatic.com/media/b824cb_f2f2857b1c184e138ed762b01f99c333~mv2.jpg/v1/fill/w_107,h_60,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/ChemComm-Fluoro-Li_edited.jpg)
Spennacchio M., Colella M., Andresini M., Dibenedetto R.S., Graziano E., Aramini A., Degennaro L., Luisi R.
Unlocking geminal fluorohaloalkanes in nucleophilic fluoroalkylation chemistry: generation and trapping of lithiumfluorocarbenoids enabled by flow microreactors
ChemComm, 2022 59 (10), 1373 - 1376
DOI: 10.1039/d2cc06717j
![RChemEng-Vile_edited.jpg](https://static.wixstatic.com/media/b824cb_e5ba12dac0654d548efa0d40c42bf597~mv2.jpg/v1/fill/w_107,h_62,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/RChemEng-Vile_edited.jpg)
Sivo A., Kim T.K., Ruta V., Luisi R., Osorio-Tejada J., Escriba-Gelonch M., Hessel V., Sponchioni M., Vilé G.
Enhanced flow synthesis of small molecules by in-line integration of sequential catalysis and benchtop twin-column continuous chromatography
React. Chem. Eng., 2022, 7 (12), 2650 - 2658
DOI: 10.1039/d2re00242f
![Chapter-Het-Lithium_edited.jpg](https://static.wixstatic.com/media/b824cb_eb47050aa5a24ba895c81dbabd2198f2~mv2.jpg/v1/fill/w_107,h_82,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/Chapter-Het-Lithium_edited.jpg)
Luisi R., Degennaro L., Colella M.
Lithium Complexes in Organic Synthesis
(2022) Comprehensive Organometallic Chemistry IV: Volume 1-15, 1-15, pp. 2 - 56
DOI: 10.1016/B978-0-12-820206-7.00049-4
![Oxazolinyl-Azetidine-Molecules_edited.jp](https://static.wixstatic.com/media/b824cb_1da7f143a9474888b03cb2b4e1c8e664~mv2.jpg/v1/fill/w_107,h_74,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/Oxazolinyl-Azetidine-Molecules_edited_jp.jpg)
Musci P., Colella M., Altomare A., Romanazzi G., Sheikh N.S., Degennaro L., Luisi R.
Dynamic Phenomena and Complexation Effects in the α-Lithiation and Asymmetric Functionalization of Azetidines
Molecules, 2022, 27 (9), 2847
DOI: 10.3390/molecules27092847
![Molbank_edited.jpg](https://static.wixstatic.com/media/b824cb_e5429cece8c447cda2b01f5a061f9a1c~mv2.jpg/v1/fill/w_107,h_59,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/Molbank_edited.jpg)
Tota A., Andresini M., Colella M., Dibenedetto R.S., Degennaro L., Luisi R.
(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl (R)-4-methylbenzenesulfonimidate
(2022) MolBank, 2022 (4), art. no. M1518
DOI: 10.3390/M1518
![Molecules-Kaunas.jpg](https://static.wixstatic.com/media/b824cb_1aea32abe3b246f8862eb508908538dc~mv2.jpg/v1/fill/w_159,h_53,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/Molecules-Kaunas.jpg)
Urbonavičius A., Fortunato G., Ambrazaitytė E., Plytninkienė E., Bieliauskas A., Milišiūnaitė V., Luisi R., Arbačiauskienė E., Krikštolaitytė S., Šačkus A.
Synthesis and Characterization of Novel Heterocyclic Chalcones from 1-Phenyl-1H-pyrazol-3-ol
Molecules, 2022, 27 (12), 3752
DOI: 10.3390/molecules27123752
2021
![ABB-ACIE-Flow-2021.jpg](https://static.wixstatic.com/media/b824cb_0b302a95035847f7baeb15f6be85a682~mv2.jpg/v1/fill/w_104,h_57,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/ABB-ACIE-Flow-2021.jpg)
P. Musci,T. von Keutz, F. Belaj,Prof. L. Degennaro, D. Cantillo, C. O. Kappe, R. Luisi
Flow Technology for Telescoped Generation, Lithiation and Electrophilic (C3) Functionalization of Highly Strained 1-Azabicyclo[1.1.0]butanes
Angew. Chem. Int. Ed. Engl. 2021, 60, 6395-6399
![OL-Sulfilimines_edited.jpg](https://static.wixstatic.com/media/b824cb_68a40d6f362c4752b35528776d679412~mv2.jpg/v1/fill/w_112,h_53,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/OL-Sulfilimines_edited.jpg)
Andresini, M.; Spennacchio, M.; Colella, M.; Losito, G.; Aramini, A.; Degennaro, L.; Luisi, R.
Sulfinimidate Esters as an Electrophilic Sulfinimidoyl Motif Source: Synthesis of N-Protected Sulfilimines from Grignard Reagents.
Organic Letters 2021, 23 (17), 6850-6854.
![JOC-Azetidine-Flow-2021_edited.png](https://static.wixstatic.com/media/b824cb_5f4c2aa037e7445fb9ec1d1376f30339~mv2.png/v1/fill/w_115,h_53,al_c,q_85,usm_0.66_1.00_0.01,blur_2,enc_auto/JOC-Azetidine-Flow-2021_edited.png)
M. Colella, P. Musci, D. Cannillo, M. Spennacchio, A. Aramini, L. Degennaro, R. Luisi
Development of a Continuous Flow Synthesis of 2-Substituted Azetines and 3-Substituted Azetidines by Using a Common Synthetic Precursor
J. Org. Chem. 2021, 86, 20, 13943–13954
![ADSC-N-N-Transfer.JPG](https://static.wixstatic.com/media/b824cb_1e6f656e7f1b426693f7daea0521adb7~mv2.jpg/v1/fill/w_159,h_53,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/ADSC-N-N-Transfer_JPG.jpg)
Tota A., Colella M., Carlucci C., Aramini A., Clarkson G., Degennaro L., Bull J.A., Luisi R.
N−N Bond Formation Using an Iodonitrene as an Umpolung of Ammonia: Straightforward and Chemoselective Synthesis of Hydrazinium Salts
Adv. Syn. Cat., 2021, 363 (1), 194 - 199
DOI: 10.1002/adsc.202001047
![JOC-Vinyl-Sulfoximine_edited.jpg](https://static.wixstatic.com/media/b824cb_81d452f404194f4495f4982d5ff34d77~mv2.jpg/v1/fill/w_104,h_58,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/JOC-Vinyl-Sulfoximine_edited.jpg)
Craven G.B., Briggs E.L., Zammit C.M., McDermott A., Greed S., Affron D.P., Leinfellner C., Cudmore H.R., Tweedy R.R., Luisi R., Bull J.A., Armstrong A.
Synthesis and Configurational Assignment of Vinyl Sulfoximines and Sulfonimidamides
J. Org. Chem., 2021, 86 (11), 7403 - 7424
DOI: 10.1021/acs.joc.1c00373
![Beilstein-Azirine_edited.jpg](https://static.wixstatic.com/media/b824cb_0f724d551950409097511a2645dd8068~mv2.jpg/v1/fill/w_114,h_53,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/Beilstein-Azirine_edited.jpg)
Andresini M., Degannaro L., Luisi R.
A sustainable strategy for the straightforward preparation of 2H-azirines and highly functionalized NH-aziridines from vinyl azides using a single solvent flow-batch approach
Beilstein Journal of Organic Chemistry, 2021 17, 203 - 209
DOI: 10.3762/BJOC.17.20
![OBC-Sxecci-Spiroepox.JPG](https://static.wixstatic.com/media/b824cb_9c4ba89f277a4b58aefb207057bc922e~mv2.jpg/v1/fill/w_159,h_53,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/OBC-Sxecci-Spiroepox_JPG.jpg)
Cocco A., Rubanu M.G., Sechi M.L., Frongia A., Mastrorilli P., Degennaro L., Colella M., Luisi R., Secci F.
Lithiated three-membered heterocycles as chiral nucleophiles in the enantioselective synthesis of 1-oxaspiro[2,3]hexanes
Org. Biom. Chem., 2021, 19 (9), 1945 - 1949
DOI: 10.1039/d0ob00771d
![Diapositiva6_edited.jpg](https://static.wixstatic.com/media/b824cb_d1df08c9f8d6466b993045da3b67eb7d~mv2.jpg/v1/fill/w_104,h_85,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/Diapositiva6_edited.jpg)
M. Andresini, A. Tota, L. Degennaro, J. A. Bull, R. Luisi
Synthesis and Transformations of NH-Sulfoximines.
Chemistry - A European Journal 2021, 27, 17293-17321.
![Chapter-Azetidine-CHC_edited.jpg](https://static.wixstatic.com/media/b824cb_d7b8ea3344674fe298d0123f4240b9c1~mv2.jpg/v1/fill/w_103,h_88,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/Chapter-Azetidine-CHC_edited.jpg)
Andresini M., Degennaro L., Luisi R.
Azetidines, Azetines and Azetes: Monocyclic
(2021) Comprehensive Heterocyclic Chemistry IV, pp. 1 - 115
DOI: 10.1016/B978-0-12-818655-8.00155-4
![Arkivoc-Review.JPG](https://static.wixstatic.com/media/b824cb_271111aed41443e5b1c0523a7987d5f7~mv2.jpg/v1/fill/w_159,h_53,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/Arkivoc-Review_JPG.jpg)
Andresini M., Colella M., Degennaro L., Luisi R.
Hypervalent iodine (III) reagents and ammonia as useful combination for highly chemoselective N-transfer to low-valent organosulfur compounds and amines
(2021) Arkivoc, 2022 (4)
DOI: 10.24820/ark.5550190.p011.654