RECENT PUBLICATIONS
2020
Musci, P.; Colella, M.; Sivo, A.; Romanazzi, G.; Degennaro, L.; Luisi, R.
Flow Microreactor Technology for Taming Highly Reactive Chloroiodomethyllithium Carbenoid: Direct and Chemoselective Synthesis of α‑Chloroaldehydes
Organic Letters 2020, asap, doi:10.1021/acs.orglett.0c01085
Colella, M.; Tota, A.; Takahashi, Y.; Higuma, R.; Degennaro, L.; Nagaki, A.; Luisi, R
Fluoro-substituted Methyllithium Chemistry Based on A Novel External Quenching Method Using Flow Microreactors
Angew. Chem. Int. Ed. 2020, asap, doi:10.1002/anie.202003831
Colella, M.; Nagaki, A.; Luisi, R.
Flow Technology for the Genesis and Use of (Highly) Reactive Organometallic Reagents.
Open Access Review
Chemistry - A European Journal 2020, 26 (1), 19-32
Musio, B.;.et al.... Luisi, R.; Gallo, V.
A community-built calibration system: The case study of quantification of metabolites in grape juice by qNMR spectroscopy.
Talanta, 214. doi:10.1016/j.talanta.2020.120855
Takahashi, Y.; Ashikari, Y.; Takumi, M.; Shimizu, Y.; Jiang, Y.; Higuma, R.; Ishikawa, S.; Sakaue, H.; Shite, I.; Maekawa, K.; Aizawa, Y.; Yamashita, H.; Yonekura, Y.; Colella, M.; Luisi, R.; Takegawa, T.; Fujita, C.; Nagaki, A.,
Synthesis of Biaryls Having a Piperidylmethyl Group Based on Space Integration of Lithiation, Borylation, and Suzuki–Miyaura Coupling.
European Journal of Organic Chemistry 2020, 2020 (5), 618-622.
2019
Briggs, E. L.; Tota, A.; Colella, M.; Degennaro, L.; Luisi, R.; Bull, J. A.
Synthesis of Sulfonimidamides from Sulfenamides via an Alkoxy-Amino-λ6 -Sulfanenitrile Intermediate.
Angewandte Chemie International Edition 2019, 58, 14303-14310
Colella, M.; Tota, A.; Großjohann, A.; Carlucci, C.; Aramini, A.; Sheikh, N. S.; Degennaro, L.; Luisi, R.
Straightforward Chemo- and Stereoselective Fluorocyclopropanation of Allylic Alcohols: Exploiting the Electrophilic Nature of the Not so Elusive Fluoroiodomethyllithium.
Chemical Communications 2019, 55, 8430
Monticelli,S.; Colella, C.; Tota, A.; Pillari, V.; Langer, T.; Holzer, W.; Degennaro, L.; Pace, V.; Luisi, R.
Modular and Chemoselective Strategy for the Direct Access to α-Fluoroepoxides and aziridines via the Addition of Fluoroiodomethyl-lithium to Carbonyl-like Compounds
Organic Letters 2018, 22, 584
Musci, P.; Colella, M.; Fanelli, F.; Altomare, A.; Pisano, L.; Carlucci, C.; Luisi, R.; Degennaro, L.
Stereo- and Enantioselective Addition of Organolithiums to 2-Oxazolinylazetidines as a Synthetic Route to 2-Acylazetidines.
Frontiers in Chemistry 2019, 7.
De Angelis, S.; Celestini, P.; Purgatorio, R.; Degennaro, L.; Rebuzzini, G.; Luisi, R.; Carlucci, C.
Development of a continuous flow synthesis of propranolol: tackling a competitive side reaction
Journal of Flow Chemistry 2019, 9, 231-236.
De Angelis, S.; Triminì, A.; Franco, M.; Degennaro, L.; Romanazzi, G.; Carlucci, C.; González, A.; Sainz, R.; Goñi, A.; Ferritto, R.; Aceña, J. L.; Luisi, R. Belén Cid, M.
A Study of Graphene-Based Copper Catalysts: Copper(I) Nanoplatelets for Batch and Continuous-Flow Applications
Chemistry - An Asian Journal 2019, 14, 3011-3018.
Lauder, K.; Masci, D.; Toscani, A.; Al Mekdad, A.; Black, G. W.; Brown, N. L.; Turner, N. J.; Luisi, R.; Castagnolo, D.
A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution
Organic and Biomolecular Chemistry 2019, 17, 8982-8986.
Colella, M.; Musci, P.; Luisi, R.; Degennaro, L.
Synthesis and use of halodifluoromethyl heterocycles
Targets in Heterocyclic Systems, 2019; Vol. 23; pp 384-398.
Carlucci, C.; Andresini, M.; Degennaro, L.; Luisi, R.
Benchmarking acidic and basic catalysis for a robust production of biofuel from waste cooking oil.
Catalysts 2019, 9, 1050.
Carlucci, C.; Degennaro, L.; Luisi, R.
Titanium Dioxide as a Catalyst in Biodiesel Production.
Catalysts 2019, 9 (1), 75
2018
Colella, M.; Carlucci, C.; Luisi, R.
Supported Catalysts for Continuous Flow Synthesis
Topics in Current Chemistry 2018, 376, 46
Tota, A.; St John-Campbell, S.; Briggs, E. L.; Estévez, G. O.; Afonso, M.; Degennaro, L.; Luisi, R.; Bull, J. A.
Highly Chemoselective NH- and O-Transfer to Thiols Using Hypervalent Iodine Reagents: Synthesis of Sulfonimidates and Sulfonamides.
Org. Lett. 2018, 20, 2599-2602
De Angelis, Hone, C.; Degennaro, L.; Celestini, P.; Luisi, R.; Kappe, O.
Sequential α-Lithiation and Aerobic Oxidation of an Arylacetic Acid - Continuous-Flow Synthesis of Cyclopentyl Mandelic Acid
J. Flow. Chem. 2018, 8, 109–116
De Angelis, S.; Carlucci, C.; de Candia, M.; Rebuzzini, G.; Celestini, P.; Riscazzi, M.; Luisi, R.; Degennaro, L.,
Targeting a Mirabegron precursor by BH3-mediated continuous flow reduction process.
Catalysis Today 2018, 308, 81-85
Andresini, M.; De Angelis, S.; Uricchio, A.; Visaggio, A.; Romanazzi, G.; Ciriaco, F.; Corriero, N.; Degennaro, L.; Luisi, R.
Azetidine-Borane Complexes: Synthesis, Reactivity, and Stereoselective Functionalization.
J. Org. Chem. 2018, 83 (17), 10221-10230
Luisi, R.; Degennaro, L.,
Use of azetidine scaffolds in stereoselective transformations (microreview).
Chem. Heter. Comp. 2018, 54, 400-402
Carlucci, C.; Tota, A.; Colella, M.; Ronamazzi, G.; Clarkson, G. J.; Luisi, R.; Degennaro, L.
Use of Hypervalent Iodine in the Synthesis of Isomeric Dihydrooxazoles.
Chem. Heter. Comp. 2018, 54, 428-436
Colella, M.; Musci, P.; Carlucci, C.; Lillini, S.; Tomassetti, M.; Aramini, A.; Degennaro, L.; Luisi, R.
1,3-Dibromo-1,1-difluoro-2-propanone as Useful Synthon for a Chemoselective Preparation of 4-Bromodifluoromethyl Thiazoles
ACS Omega, 2018, 3, 14841–14848
2017
Parisi, G.; Colella, M.; Monticelli, S.; Romanazzi, G.; Holzer, W.; Langer, T.; Degennaro, L.; Pace, V.; Luisi, R.
Exploiting a "beast" in carbenoid chemistry: Development of a straightforward direct nucleophilic fluoromethylation strategy.
J. Am. Chem. Soc. 2017, 139, 13648-13651
Tota, A.; Zenzola, M.; Chawner, S. J.; John-Campbell, S. S.; Carlucci, C.; Romanazzi, G.; Degennaro, L.; Bull, J. A.; Luisi, R.
Synthesis of NH-sulfoximines from sulfides by chemoselective one-pot N- and O-transfers.
Chem. Commun. 2017, 53, 348-351
Parisi, G.; Degennaro, L.; Carlucci, C.; De Candia, M.; Mastrorilli, P.; Roller, A.; Holzer, W.; Altomare, C. D.; Pace, V.; Luisi, R.
A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles
Org. Biom. Chem. 2017, 15, 5000-5015
Tota, A.; Fanelli, F.; Falcicchio, A.; Luisi, R.; Degennaro, L.
Functionalization of four-membered cyclic sulfoximines by a convenient lithiation/trapping sequence
Chem. Het Comp. 2017, 53, 322-328
Romanazzi, G.; Degennaro, L.; Mastrorilli, P.; Luisi, R.
Chiral Switchable Catalysts for Dynamic Control of Enantioselectivity
ACS Catalysis 2017, 7, 4100-4114
Fanelli, F.; Parisi, G.; Degennaro, L.; Luisi, R.
Contribution of microreactor technology and flow chemistry to the development of green and sustainable synthesis
Beilstein J. Org. Chem. 2017, 13, 520-542
Degennaro, L.; Tota, A.; De Angelis, S.; Andresini, M.; Cardellicchio, C.; Capozzi, M. A.; Romanazzi, G.; Luisi, R.
A Convenient, Mild, and Green Synthesis of NH-Sulfoximines in Flow Reactors
Eur. J. Org. Chem. 2017, 6486-6490
De Angelis, S.; Celestini, P.; Rebuzzini, G.; Degennaro, L.; Luisi, R.
A Practical 11B NMR Evaluation of BH3 Titer in Commercial Solutions
Synthesis 2017, 49, 1969-1971
Bull, J. A.; Degennaro, L.; Luisi, R.
Straightforward Strategies for the Preparation of NH-Sulfox-imines: A Serendipitous Story
Synlett 2017, 28, 2525-2538
Degennaro, L.; Zenzola, M.; Laurino, A.; Cavalluzzi, M. M.; Franchini, C.; Habtemariam, S.; Matucci, R.; Luisi, R.; Lentini, G.
2-Arylazetidines as ligands for nicotinic acetylcholine receptors
Chem. Heter. Comp. 2017, 53, 329-334
Denora, N.; Lopedota, A.; de Candia, M.; Cellamare, S.; Degennaro, L.; Mele, A.; Tricarico, D.; Cutrignelli, A.; Laquintana, V.; Altomare, C. D.; Franco, M.; Dimiccoli, V.; Tolomeo, A.; Scilimati, A.; Luisi, R.
Pharmaceutical development of novel lactate-based 6-fluoro-L-DOPA formulations
Eur. J. Pharm. Sci. 2017, 99, 361-368
Antermite, D.; Degennaro, L.; Luisi, R.
Recent advances in the chemistry of metallated azetidines
Org. Biom. Chem. 2017, 15, 34-50
2016
Zenzola, M.; Doran, R.; Degennaro, L.; Luisi, R.; Bull, J. A.
Transfer of Electrophilic NH Using Convenient Sources of Ammonia: Direct Synthesis of NH Sulfoximines from Sulfoxides
Angew. Chem. Int. Ed. 2016, 55, 7203-7207
Pisano, L.; Degennaro, L.; Carraro, M.; Azzena, U.; Fanelli, F.; Mastrorilli, P.; Luisi, R.
Computational NMR as Useful Tool for Predicting Structure and Stereochemistry of Four-Membered Sulfur Heterocycles
Eur. J. Org. Chem. 2016, 2016, 3252-3258
Parisi, G.; Zenzola, M.; Capitanelli, E.; Carlucci, C.; Romanazzi, G.; Pisano, L.; Degennaro, L.; Luisi, R.
Exploiting structural and conformational effects for a site-selective lithiation of azetidines
Pure Appl. Chem. 2016, 88, 631-648
Degennaro, L.; Nagaki, A.; Moriwaki, Y.; Romanazzi, G.; Dell'anna, M. M.; Yoshida, J. I.; Luisi, R.
Flow microreactor synthesis of 2,2-disubstituted oxetanes via 2-phenyloxetan-2-yl lithium
Open Chem. 2016, 14, 377-382
Degennaro, L.; Maggiulli, D.; Carlucci, C.; Fanelli, F.; Romanazzi, G.; Luisi, R.
A direct and sustainable synthesis of tertiary butyl esters enabled by flow microreactors
Chem. Commun. 2016, 52, 9554-9557
Degennaro, L.; Carlucci, C.; De Angelis, S.; Luisi, R.
Flow technology for organometallic-mediated synthesis
J. Flow Chem. 2016, 6, 136-166
De Angelis, S.; De Renzo, M.; Carlucci, C.; Degennaro, L.; Luisi, R.
A convenient enantioselective CBS-reduction of arylketones in flow-microreactor systems
Org. Biom. Chem. 2016, 14, 4304-4311
2015
Zenzola, M.; Doran, R.; Luisi, R.; Bull, J. A.
Synthesis of Sulfoximine Carbamates by Rhodium-Catalyzed Nitrene Transfer of Carbamates to Sulfoxides
J. Org. Chem.2015, 80, 6391-6399
Parisi, G.; Capitanelli, E.; Pierro, A.; Romanazzi, G.; Clarkson, G. J.; Degennaro, L.; Luisi, R.
Easy access to constrained peptidomimetics and 2,2-disubstituted azetidines by the unexpected reactivity profile of α-lithiated N-Boc-azetidines
Chem. Commun. 2015, 51, 15588-15591
Degennaro, L.; Pisano, L.; Parisi, G.; Mansueto, R.; Clarkson, G. J.; Shipman, M.; Luisi, R.
Nitrogen Stereodynamics and Complexation Phenomena as Key Factors in the Deprotonative Dynamic Resolution of Alkylideneaziridines: A Spectroscopic and Computational Study
J. Org. Chem. 2015, 80, 6411-6418
Pati, M. L.; Abate, C.; Contino, M.; Ferorelli, S.; Luisi, R.; Carroccia, L.; Niso, M.; Berardi, F.
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate P-glycoprotein (P-gp) activity from 2 receptor affinity in mixed P-gp/σ2 receptor agents
Eur. J. Med. Chem. 2015, 89, 691-700
Degennaro, L.; Fanelli, F.; Giovine, A.; Luisi, R.
External trapping of halomethyllithium enabled by flow microreactors
Adv. Synth. Cat. 2015, 357, 21-27
Degennaro, L.; Carroccia, L.; Parisi, G.; Zenzola, M.; Romanazzi, G.; Fanelli, F.; Pisano, L.; Luisi, R.
Regio- and Stereoselective Synthesis of Sulfur-Bearing Four-Membered Heterocycles: Direct Access to 2,4-Disubstituted Thietane 1-Oxides
J. Org. Chem. 2015, 80, 12201-12211
Castagnolo, D.; Degennaro, L.; Luisi, R.; Clayden, J.
Enantioselective carbolithiation of S-alkenyl-N-aryl thiocarbamates: Kinetic and thermodynamic control
Org. Biom. Chem. 2015, 13, 2330-2340
2014
Degennaro, L.; Zenzola, M.; Trinchera, P.; Carroccia, L.; Giovine, A.; Romanazzi, G.; Falcicchio, A.; Luisi, R.
Regioselective functionalization of 2-arylazetidines: Evaluating the ortho-directing ability of the azetidinyl ring and the α-directing ability of the N-substituent
Chem. Commun. 2014, 50, 1698-1700
Zenzola, M.; Degennaro, L.; Trinchera, P.; Carroccia, L.; Giovine, A.; Romanazzi, G.; Mastrorilli, P.; Rizzi, R.; Pisano, L.; Luisi, R.
Harnessing the ortho-directing ability of the azetidine ring for the regioselective and exhaustive functionalization of arenes
Chem. Eur. J. 2014, 20, 12190-12200
Pace, V.; Luisi, R.
Expanding the synthetic portfolio of organolithiums: Direct use in catalytic cross-coupling reactions
ChemCatChem 2014, 6, 1516-1519
Mansueto, R.; Degennaro, L.; Brière, J. F.; Griffin, K.; Shipman, M.; Florio, S.; Luisi, R.
Stereocontrolled lithiation/trapping of chiral 2-alkylideneaziridines: Investigation into the role of the aziridine nitrogen stereodynamics
Org. Biom. Chem. 2014, 12, 8505-8511
Giovine, A.; Muraglia, M.; Florio, M. A.; Rosato, A.; Corbo, F.; Franchini, C.; Musio, B.; Degennaro, L.; Luisi, R.
Synthesis of functionalized arylaziridines as potential antimicrobial agents
Molecules 2014, 19, 11505-11519
Degennaro, L.; Trinchera, P.; Luisi, R.
Recent advances in the stereoselective synthesis of aziridines
Chem. Rev. 2014, 114, 7881-7929
Carroccia, L.; Degennaro, L.; Romanazzi, G.; Cuocci, C.; Pisano, L.; Luisi, R.
Straightforward access to 4-membered sulfurated heterocycles: Introducing a strategy for the single and double functionalization of thietane 1-oxide
Org. Biom. Chem. 2014, 12, 2180-2184
Capriati, V.; Florio, S.; Luisi, R.
Complexation Phenomena and Dynamics at Work in the Lithiation Reactions of Small-Ring Heterocycles: Regio- and Stereoselectivity
Eur. J. Org. Chem. 2014, 2014, 5397-5417
Azzena, U.; Carraro, M.; Meloni, C.; Murgia, I.; Pisano, L.; Pittalis, M.; Luisi, R.; Musio, B.; Degennaro, L.
Regio- and stereochemistry of Na-mediated reductive cleavage of alkyl aryl ethers
Tetrahedron Asymmetry 2014, 25, 1550-1554
2013
Tota, A.; Zenzola, M.; Chawner, S. J.; John-Campbell, S. S.; Carlucci, C.; Romanazzi, G.; Degennaro, L.; Bull, J. A.; Luisi, R.
Synthesis of NH-sulfoximines from sulfides by chemoselective one-pot N- and O-transfers.
Chem. Commun. 2017, 53, 348-351
Castagnolo, D.; Foley, D. J.; Berber, H.; Luisi, R.; Clayden, J.
Carbolithiation of S-alkenyl-N-aryl thiocarbamates: Carbanion arylation in a connective route to tertiary thiols
Org. Lett. 2013, 15, 2116-2119
Carroccia, L.; Musio, B.; Degennaro, L.; Romanazzi, G.; Luisi, R.
Microreactor-mediated organocatalysis: Towards the development of sustainable domino reactions
J. Flow Chem. 2013, 3, 29-33
2010 - 2012
Trinchera, P.; Musio, B.; Degennaro, L.; Moliterni, A.; Falcicchio, A.; Luisi, R.
One-pot preparation of piperazines by regioselective ring-opening of non-activated arylaziridines
Org. Biom. Chem. 2012, 10, 1962-1965
Degennaro, L.; Mansueto, R.; Carenza, E.; Rizzi, R.; Florio, S.; Pratt, L. M.; Luisi, R.
Nitrogen dynamics and reactivity of chiral aziridines: Generation of configurationally stable aziridinyllithium compounds
Chem. Eur. J. 2011, 17, 4992-5003
De Ceglie, M. C.; Musio, B.; Affortunato, F.; Moliterni, A.; Altomare, A.; Florio, S.; Luisi, R.
Solvent- and temperature-dependent functionalisation of enantioenriched aziridines
Chem. Eur. J. 2011, 17, 286-296
De Ceglie, M. C.; Degennaro, L.; Falcicchio, A.; Luisi, R.
Restricted rotations and stereodynamics of aziridine-2-methanol derivatives
Tetrahedron 2011, 67, 9382-9388
Azzena, U.; Dettori, G.; Pisano, L.; Musio, B.; Luisi, R.
BH3-promoted stereoselective β-lithiation of N-alkyl-2-phenylaziridines
J. Org. Chem. 2011, 76, 2291-2295
Florio, S.; Luisi, R.
Aziridinyl anions: Generation, reactivity, and use in modern synthetic chemistry
Chem. Rev. 2010, 110, 5128-5157
Luisi, R.; Giovine, A.; Florio, S.
New arylaziridinyldifluoroborates: Useful Suzuki-Miyaura reagents
Chem. Eur. J. 2010, 16, 2683-2687