RECENT PUBLICATIONS

2020

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Tota, A., Carlucci, C., Pisano, L., Degennaro, L., Cutolo, G., Clarkson, G., Romanazzi, G., Bull, J. A., Rollin, P., Luisi, R.


Synthesis of glycosyl sulfoximines by a highly chemo- And stereoselective NH- And O-transfer to thioglycosides

Organic and Biomolecular Chemistry 2020, 18, 3893-3897

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Colella, M., Degennaro, L., Luisi, R.

Continuous flow synthesis of heterocycles: A recent update on the flow synthesis of indoles
      

Molecules 2020, 25, 3242 - Open Acess

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   Andresini, M., Degennaro, L., Luisi, R. 

The renaissance of strained 1-azabicyclo[1.1.0]butanes as useful reagents for the synthesis of functionalized azetidines      

Organic and Biomolecular Chemistry 2020, 18, 5798-5810

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 Andresini, M., Spennacchio, M., Ciriaco F.,Clarkson G. Romanazzi, G., Degennaro, L., Luisi, R.   

Synthesis of Sulfinamidines and Sulfinimidate Esters by Transfer of Nitrogen to Sulfenamides

Organic Letters 2020, 22, 7129-7134

https://doi.org/10.1021/acs.orglett.0c02471

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Musci, P.; Colella, M.; Sivo, A.; Romanazzi, G.; Degennaro, L.; Luisi, R.

Flow Microreactor Technology for Taming Highly Reactive Chloroiodomethyllithium Carbenoid: Direct and Chemoselective Synthesis of α‑Chloroaldehydes

Organic Letters 2020,  doi:10.1021/acs.orglett.0c01085

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Colella, M.; Tota, A.; Takahashi, Y.; Higuma, R.; Degennaro, L.; Nagaki, A.; Luisi, R

Fluoro-substituted Methyllithium Chemistry Based on A Novel External Quenching Method Using Flow Microreactors

Angew. Chem. Int. Ed. 2020, doi:10.1002/anie.202003831

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Colella, M.; Nagaki, A.; Luisi, R.

 

Flow Technology for the Genesis and Use of (Highly) Reactive Organometallic Reagents. 

Open Access Review

Chemistry - A European Journal 2020, 26 (1), 19-32

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Musio, B.;.et al.... Luisi, R.; Gallo, V.

 

A community-built calibration system: The case study of quantification of metabolites in grape juice by qNMR spectroscopy. 

Talanta, 214. doi:10.1016/j.talanta.2020.120855

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Takahashi, Y.;  Ashikari, Y.;  Takumi, M.;  Shimizu, Y.;  Jiang, Y.;  Higuma, R.;  Ishikawa, S.;  Sakaue, H.;  Shite, I.;  Maekawa, K.;  Aizawa, Y.;  Yamashita, H.;  Yonekura, Y.;  Colella, M.;  Luisi, R.;  Takegawa, T.;  Fujita, C.; Nagaki, A.,

Synthesis of Biaryls Having a Piperidylmethyl Group Based on Space Integration of Lithiation, Borylation, and Suzuki–Miyaura Coupling. 

European Journal of Organic Chemistry 2020, 2020 (5), 618-622.

2019

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Briggs, E. L.; Tota, A.; Colella, M.; Degennaro, L.; Luisi, R.; Bull, J. A.

Synthesis of Sulfonimidamides from Sulfenamides via an Alkoxy-Amino-λ6 -Sulfanenitrile Intermediate.

Angewandte Chemie International Edition 2019, 58, 14303-14310

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Colella, M.; Tota, A.; Großjohann, A.; Carlucci, C.; Aramini, A.; Sheikh, N. S.; Degennaro, L.; Luisi, R.

 

Straightforward Chemo- and Stereoselective Fluorocyclopropanation of Allylic Alcohols: Exploiting the Electrophilic Nature of the Not so Elusive Fluoroiodomethyllithium.

Chemical Communications 2019, 55, 8430

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Monticelli,S.; Colella, C.; Tota, A.;  Pillari, V.; Langer, T.; Holzer, W.; Degennaro, L.; Pace, V.; Luisi, R.

 

Modular and Chemoselective Strategy for the Direct Access to α-Fluoroepoxides and aziridines via the Addition of Fluoroiodomethyl-lithium to Carbonyl-like Compounds 

Organic Letters 2018, 22, 584

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Musci, P.; Colella, M.; Fanelli, F.; Altomare, A.; Pisano, L.; Carlucci, C.; Luisi, R.; Degennaro, L. 

Stereo- and Enantioselective Addition of Organolithiums to 2-Oxazolinylazetidines as a Synthetic Route to 2-Acylazetidines.

Frontiers in Chemistry 2019, 7. https://doi.org/10.3389/fchem.2019.00614

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De Angelis, S.; Celestini, P.; Purgatorio, R.; Degennaro, L.; Rebuzzini, G.; Luisi, R.; Carlucci, C. 

 

Development of a continuous flow synthesis of propranolol: tackling a competitive side reaction 

Journal of Flow Chemistry 2019, 9, 231-236.

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De Angelis, S.;  Triminì, A.;  Franco, M.; Degennaro, L.; Romanazzi, G.; Carlucci, C.; González, A.; Sainz, R.;  Goñi, A.; Ferritto, R.;  Aceña, J. L.;  Luisi, R.   Belén Cid, M.

A Study of Graphene-Based Copper Catalysts: Copper(I) Nanoplatelets for Batch and Continuous-Flow Applications

Chemistry - An Asian Journal 2019, 14, 3011-3018.

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Lauder, K.; Masci, D.; Toscani, A.; Al Mekdad, A.; Black, G. W.; Brown, N. L.; Turner, N. J.; Luisi, R.; Castagnolo, D. 

A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution

Organic and Biomolecular Chemistry 2019, 17, 8982-8986.

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Colella, M.; Musci, P.; Luisi, R.; Degennaro, L.

Synthesis and use of halodifluoromethyl heterocycles

Targets in Heterocyclic Systems, 2019; Vol. 23; pp 384-398.

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Carlucci, C.; Andresini, M.; Degennaro, L.; Luisi, R

Benchmarking acidic and basic catalysis for a robust production of biofuel from waste cooking oil. 

Catalysts 2019, 9, 1050. 

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 Carlucci, C.; Degennaro, L.; Luisi, R.

 

 

Titanium Dioxide as a Catalyst in Biodiesel Production.

Catalysts 2019, 9 (1), 75

2018

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Colella, M.; Carlucci, C.; Luisi, R.

 

Supported Catalysts for Continuous Flow Synthesis

Topics in Current Chemistry 2018, 376, 46

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Tota, A.; St John-Campbell, S.; Briggs, E. L.; Estévez, G. O.; Afonso, M.; Degennaro, L.; Luisi, R.; Bull, J. A.

Highly Chemoselective NH- and O-Transfer to Thiols Using Hypervalent Iodine Reagents: Synthesis of Sulfonimidates and Sulfonamides.

Org. Lett. 2018, 20, 2599-2602

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De Angelis, Hone, C.; Degennaro, L.; Celestini, P.; Luisi, R.; Kappe, O. 

Sequential α-Lithiation and Aerobic Oxidation of an Arylacetic Acid - Continuous-Flow Synthesis of Cyclopentyl Mandelic Acid

J. Flow. Chem. 2018, 8, 109–116

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De Angelis, S.; Carlucci, C.; de Candia, M.; Rebuzzini, G.; Celestini, P.; Riscazzi, M.; Luisi, R.; Degennaro, L.,

 

Targeting a Mirabegron precursor by BH3-mediated continuous flow reduction process.

Catalysis Today 2018, 308, 81-85

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Andresini, M.; De Angelis, S.; Uricchio, A.; Visaggio, A.; Romanazzi, G.; Ciriaco, F.; Corriero, N.; Degennaro, L.; Luisi, R.

 

 Azetidine-Borane Complexes: Synthesis, Reactivity, and Stereoselective Functionalization.

J. Org. Chem. 2018, 83 (17), 10221-10230

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Luisi, R.; Degennaro, L., 

 

Use of azetidine scaffolds in stereoselective transformations (microreview).

Chem. Heter. Comp. 2018, 54, 400-402

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Carlucci, C.; Tota, A.; Colella, M.; Ronamazzi, G.; Clarkson, G. J.; Luisi, R.; Degennaro, L.

 

Use of Hypervalent Iodine in the Synthesis of Isomeric Dihydrooxazoles.

Chem. Heter. Comp. 2018, 54, 428-436

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Colella, M.; Musci, P.; Carlucci, C.; Lillini, S.; Tomassetti, M.; Aramini, A.; Degennaro, L.; Luisi, R.

1,3-Dibromo-1,1-difluoro-2-propanone as Useful Synthon for a Chemoselective Preparation of  4-Bromodifluoromethyl Thiazoles

ACS Omega, 2018, 3, 14841–14848

2017

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Parisi, G.; Colella, M.; Monticelli, S.; Romanazzi, G.; Holzer, W.; Langer, T.; Degennaro, L.; Pace, V.; Luisi, R.

 

Exploiting a "beast" in carbenoid chemistry: Development of a straightforward direct nucleophilic fluoromethylation strategy.   

J.  Am. Chem. Soc. 2017, 139, 13648-13651

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Tota, A.; Zenzola, M.; Chawner, S. J.; John-Campbell, S. S.; Carlucci, C.; Romanazzi, G.; Degennaro, L.; Bull, J. A.; Luisi, R.

 

Synthesis of NH-sulfoximines from sulfides by chemoselective one-pot N- and O-transfers.

Chem. Commun. 2017, 53, 348-351

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Parisi, G.; Degennaro, L.; Carlucci, C.; De Candia, M.; Mastrorilli, P.; Roller, A.; Holzer, W.; Altomare, C. D.; Pace, V.; Luisi, R.


A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles 
 

Org. Biom. Chem. 2017, 15, 5000-5015

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Tota, A.; Fanelli, F.; Falcicchio, A.; Luisi, R.; Degennaro, L.


Functionalization of four-membered cyclic sulfoximines by a convenient lithiation/trapping sequence 

Chem. Het Comp. 2017, 53, 322-328

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Romanazzi, G.; Degennaro, L.; Mastrorilli, P.; Luisi, R.


Chiral Switchable Catalysts for Dynamic Control of Enantioselectivity 
 

ACS Catalysis 2017, 7, 4100-4114

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Fanelli, F.; Parisi, G.; Degennaro, L.; Luisi, R.

 
Contribution of microreactor technology and flow chemistry to the development of green and sustainable synthesis 

 

Beilstein J. Org. Chem. 2017, 13, 520-542

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Degennaro, L.; Tota, A.; De Angelis, S.; Andresini, M.; Cardellicchio, C.; Capozzi, M. A.; Romanazzi, G.; Luisi, R. 


A Convenient, Mild, and Green Synthesis of NH-Sulfoximines in Flow Reactors
 

Eur. J.  Org. Chem. 2017, 6486-6490

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De Angelis, S.; Celestini, P.; Rebuzzini, G.; Degennaro, L.; Luisi, R.


A Practical 11B NMR Evaluation of BH3 Titer in Commercial Solutions
 

Synthesis 2017, 49, 1969-1971

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Bull, J. A.; Degennaro, L.; Luisi, R.


Straightforward Strategies for the Preparation of NH-Sulfox-imines: A Serendipitous Story

Synlett 2017, 28, 2525-2538

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Degennaro, L.; Zenzola, M.; Laurino, A.; Cavalluzzi, M. M.; Franchini, C.; Habtemariam, S.; Matucci, R.; Luisi, R.; Lentini, G. 


2-Arylazetidines as ligands for nicotinic acetylcholine receptors 
 

Chem. Heter. Comp. 2017, 53, 329-334

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Denora, N.; Lopedota, A.; de Candia, M.; Cellamare, S.; Degennaro, L.; Mele, A.; Tricarico, D.; Cutrignelli, A.; Laquintana, V.; Altomare, C. D.; Franco, M.; Dimiccoli, V.; Tolomeo, A.; Scilimati, A.; Luisi, R.


Pharmaceutical development of novel lactate-based 6-fluoro-L-DOPA formulations
 

Eur. J. Pharm. Sci. 2017, 99, 361-368

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Antermite, D.; Degennaro, L.; Luisi, R. 


Recent advances in the chemistry of metallated azetidines
 

Org. Biom. Chem. 2017, 15, 34-50

2016

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Zenzola, M.; Doran, R.; Degennaro, L.; Luisi, R.; Bull, J. A. 


Transfer of Electrophilic NH Using Convenient Sources of Ammonia: Direct Synthesis of NH Sulfoximines from Sulfoxides 
 

Angew. Chem. Int. Ed. 2016, 55, 7203-7207

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Pisano, L.; Degennaro, L.; Carraro, M.; Azzena, U.; Fanelli, F.; Mastrorilli, P.; Luisi, R. 


Computational NMR as Useful Tool for Predicting Structure and Stereochemistry of Four-Membered Sulfur Heterocycles 
 

Eur. J. Org. Chem. 2016, 2016, 3252-3258

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Parisi, G.; Zenzola, M.; Capitanelli, E.; Carlucci, C.; Romanazzi, G.; Pisano, L.; Degennaro, L.; Luisi, R. 


Exploiting structural and conformational effects for a site-selective lithiation of azetidines 

Pure Appl. Chem. 2016, 88, 631-648

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Degennaro, L.; Nagaki, A.; Moriwaki, Y.; Romanazzi, G.; Dell'anna, M. M.; Yoshida, J. I.; Luisi, R. 


Flow microreactor synthesis of 2,2-disubstituted oxetanes via 2-phenyloxetan-2-yl lithium 

Open Chem. 2016, 14, 377-382

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Degennaro, L.; Maggiulli, D.; Carlucci, C.; Fanelli, F.; Romanazzi, G.; Luisi, R. 


A direct and sustainable synthesis of tertiary butyl esters enabled by flow microreactors 

Chem. Commun. 2016, 52, 9554-9557

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Degennaro, L.; Carlucci, C.; De Angelis, S.; Luisi, R.


Flow technology for organometallic-mediated synthesis

J. Flow Chem. 2016, 6, 136-166

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De Angelis, S.; De Renzo, M.; Carlucci, C.; Degennaro, L.; Luisi, R. 


A convenient enantioselective CBS-reduction of arylketones in flow-microreactor systems

Org. Biom. Chem. 2016, 14, 4304-4311

2015

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Zenzola, M.; Doran, R.; Luisi, R.; Bull, J. A.


Synthesis of Sulfoximine Carbamates by Rhodium-Catalyzed Nitrene Transfer of Carbamates to Sulfoxides

J. Org. Chem.2015, 80, 6391-6399

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Parisi, G.; Capitanelli, E.; Pierro, A.; Romanazzi, G.; Clarkson, G. J.; Degennaro, L.; Luisi, R. 


Easy access to constrained peptidomimetics and 2,2-disubstituted azetidines by the unexpected reactivity profile of α-lithiated N-Boc-azetidines 

Chem. Commun. 2015, 51, 15588-15591

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Degennaro, L.; Pisano, L.; Parisi, G.; Mansueto, R.; Clarkson, G. J.; Shipman, M.; Luisi, R. 


Nitrogen Stereodynamics and Complexation Phenomena as Key Factors in the Deprotonative Dynamic Resolution of Alkylideneaziridines: A Spectroscopic and Computational Study 

J. Org. Chem. 2015, 80, 6411-6418

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Pati, M. L.; Abate, C.; Contino, M.; Ferorelli, S.; Luisi, R.; Carroccia, L.; Niso, M.; Berardi, F. 


Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate P-glycoprotein (P-gp) activity from 2 receptor affinity in mixed P-gp/σ2 receptor agents 

Eur. J. Med. Chem. 2015, 89, 691-700

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Degennaro, L.; Fanelli, F.; Giovine, A.; Luisi, R.


External trapping of halomethyllithium enabled by flow microreactors
 

Adv. Synth. Cat. 2015, 357, 21-27

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Degennaro, L.; Carroccia, L.; Parisi, G.; Zenzola, M.; Romanazzi, G.; Fanelli, F.; Pisano, L.; Luisi, R.


Regio- and Stereoselective Synthesis of Sulfur-Bearing Four-Membered Heterocycles: Direct Access to 2,4-Disubstituted Thietane 1-Oxides

J. Org. Chem. 2015, 80, 12201-12211

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Castagnolo, D.; Degennaro, L.; Luisi, R.; Clayden, J.


Enantioselective carbolithiation of S-alkenyl-N-aryl thiocarbamates: Kinetic and thermodynamic control 

Org. Biom. Chem. 2015, 13, 2330-2340

2014

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Degennaro, L.; Zenzola, M.; Trinchera, P.; Carroccia, L.; Giovine, A.; Romanazzi, G.; Falcicchio, A.; Luisi, R.


Regioselective functionalization of 2-arylazetidines: Evaluating the ortho-directing ability of the azetidinyl ring and the α-directing ability of the N-substituent 

Chem. Commun. 2014, 50, 1698-1700

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Zenzola, M.; Degennaro, L.; Trinchera, P.; Carroccia, L.; Giovine, A.; Romanazzi, G.; Mastrorilli, P.; Rizzi, R.; Pisano, L.; Luisi, R.


Harnessing the ortho-directing ability of the azetidine ring for the regioselective and exhaustive functionalization of arenes 

Chem. Eur. J. 2014, 20, 12190-12200

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Pace, V.; Luisi, R. 


Expanding the synthetic portfolio of organolithiums: Direct use in catalytic cross-coupling reactions

ChemCatChem 2014, 6, 1516-1519

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Mansueto, R.; Degennaro, L.; Brière, J. F.; Griffin, K.; Shipman, M.; Florio, S.; Luisi, R.


Stereocontrolled lithiation/trapping of chiral 2-alkylideneaziridines: Investigation into the role of the aziridine nitrogen stereodynamics

Org. Biom. Chem. 2014, 12, 8505-8511

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Giovine, A.; Muraglia, M.; Florio, M. A.; Rosato, A.; Corbo, F.; Franchini, C.; Musio, B.; Degennaro, L.; Luisi, R.


Synthesis of functionalized arylaziridines as potential antimicrobial agents

Molecules 2014, 19, 11505-11519

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Degennaro, L.; Trinchera, P.; Luisi, R.


Recent advances in the stereoselective synthesis of aziridines

Chem. Rev. 2014, 114, 7881-7929

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Carroccia, L.; Degennaro, L.; Romanazzi, G.; Cuocci, C.; Pisano, L.; Luisi, R. 


Straightforward access to 4-membered sulfurated heterocycles: Introducing a strategy for the single and double functionalization of thietane 1-oxide

Org. Biom. Chem. 2014, 12, 2180-2184

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Capriati, V.; Florio, S.; Luisi, R.


Complexation Phenomena and Dynamics at Work in the Lithiation Reactions of Small-Ring Heterocycles: Regio- and Stereoselectivity

Eur. J. Org. Chem. 2014, 2014, 5397-5417

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Azzena, U.; Carraro, M.; Meloni, C.; Murgia, I.; Pisano, L.; Pittalis, M.; Luisi, R.; Musio, B.; Degennaro, L.


Regio- and stereochemistry of Na-mediated reductive cleavage of alkyl aryl ethers
 

Tetrahedron Asymmetry 2014, 25, 1550-1554

2013

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Tota, A.; Zenzola, M.; Chawner, S. J.; John-Campbell, S. S.; Carlucci, C.; Romanazzi, G.; Degennaro, L.; Bull, J. A.; Luisi, R.

 

Synthesis of NH-sulfoximines from sulfides by chemoselective one-pot N- and O-transfers.

Chem. Commun. 2017, 53, 348-351

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Castagnolo, D.; Foley, D. J.; Berber, H.; Luisi, R.; Clayden, J. 


Carbolithiation of S-alkenyl-N-aryl thiocarbamates: Carbanion arylation in a connective route to tertiary thiols 

Org. Lett. 2013, 15, 2116-2119

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Carroccia, L.; Musio, B.; Degennaro, L.; Romanazzi, G.; Luisi, R.


Microreactor-mediated organocatalysis: Towards the development of sustainable domino reactions
 

J. Flow Chem. 2013, 3, 29-33

2010 - 2012

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Trinchera, P.; Musio, B.; Degennaro, L.; Moliterni, A.; Falcicchio, A.; Luisi, R.


One-pot preparation of piperazines by regioselective ring-opening of non-activated arylaziridines

Org. Biom. Chem. 2012, 10, 1962-1965

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Degennaro, L.; Mansueto, R.; Carenza, E.; Rizzi, R.; Florio, S.; Pratt, L. M.; Luisi, R.

 
Nitrogen dynamics and reactivity of chiral aziridines: Generation of configurationally stable aziridinyllithium compounds

 

Chem. Eur. J. 2011, 17, 4992-5003

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De Ceglie, M. C.; Musio, B.; Affortunato, F.; Moliterni, A.; Altomare, A.; Florio, S.; Luisi, R.


Solvent- and temperature-dependent functionalisation of enantioenriched aziridines
 

Chem. Eur. J. 2011, 17, 286-296

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De Ceglie, M. C.; Degennaro, L.; Falcicchio, A.; Luisi, R.


Restricted rotations and stereodynamics of aziridine-2-methanol derivatives
 

Tetrahedron 2011, 67, 9382-9388

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Azzena, U.; Dettori, G.; Pisano, L.; Musio, B.; Luisi, R. 


BH3-promoted stereoselective β-lithiation of N-alkyl-2-phenylaziridines
 

J. Org. Chem. 2011, 76, 2291-2295

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Florio, S.; Luisi, R.


Aziridinyl anions: Generation, reactivity, and use in modern synthetic chemistry 
 

Chem. Rev. 2010, 110, 5128-5157

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Luisi, R.; Giovine, A.; Florio, S.


New arylaziridinyldifluoroborates: Useful Suzuki-Miyaura reagents
 

Chem. Eur. J. 2010, 16, 2683-2687