RECENT PUBLICATIONS
2020
Tota, A., Carlucci, C., Pisano, L., Degennaro, L., Cutolo, G., Clarkson, G., Romanazzi, G., Bull, J. A., Rollin, P., Luisi, R.
Synthesis of glycosyl sulfoximines by a highly chemo- And stereoselective NH- And O-transfer to thioglycosides
Organic and Biomolecular Chemistry 2020, 18, 3893-3897
Colella, M., Degennaro, L., Luisi, R.
Continuous flow synthesis of heterocycles: A recent update on the flow synthesis of indoles
Molecules 2020, 25, 3242 - Open Acess
Andresini, M., Degennaro, L., Luisi, R.
The renaissance of strained 1-azabicyclo[1.1.0]butanes as useful reagents for the synthesis of functionalized azetidines
Organic and Biomolecular Chemistry 2020, 18, 5798-5810
Andresini, M., Spennacchio, M., Ciriaco F.,Clarkson G. Romanazzi, G., Degennaro, L., Luisi, R.
Synthesis of Sulfinamidines and Sulfinimidate Esters by Transfer of Nitrogen to Sulfenamides
Organic Letters 2020, 22, 7129-7134
Musci, P.; Colella, M.; Sivo, A.; Romanazzi, G.; Degennaro, L.; Luisi, R.
Flow Microreactor Technology for Taming Highly Reactive Chloroiodomethyllithium Carbenoid: Direct and Chemoselective Synthesis of α‑Chloroaldehydes
Organic Letters 2020, doi:10.1021/acs.orglett.0c01085
Colella, M.; Tota, A.; Takahashi, Y.; Higuma, R.; Degennaro, L.; Nagaki, A.; Luisi, R
Fluoro-substituted Methyllithium Chemistry Based on A Novel External Quenching Method Using Flow Microreactors
Angew. Chem. Int. Ed. 2020, doi:10.1002/anie.202003831
Colella, M.; Nagaki, A.; Luisi, R.
Flow Technology for the Genesis and Use of (Highly) Reactive Organometallic Reagents.
Open Access Review
Chemistry - A European Journal 2020, 26 (1), 19-32
Musio, B.;.et al.... Luisi, R.; Gallo, V.
A community-built calibration system: The case study of quantification of metabolites in grape juice by qNMR spectroscopy.
Talanta, 214. doi:10.1016/j.talanta.2020.120855
Takahashi, Y.; Ashikari, Y.; Takumi, M.; Shimizu, Y.; Jiang, Y.; Higuma, R.; Ishikawa, S.; Sakaue, H.; Shite, I.; Maekawa, K.; Aizawa, Y.; Yamashita, H.; Yonekura, Y.; Colella, M.; Luisi, R.; Takegawa, T.; Fujita, C.; Nagaki, A.,
Synthesis of Biaryls Having a Piperidylmethyl Group Based on Space Integration of Lithiation, Borylation, and Suzuki–Miyaura Coupling.
European Journal of Organic Chemistry 2020, 2020 (5), 618-622.
2019
Briggs, E. L.; Tota, A.; Colella, M.; Degennaro, L.; Luisi, R.; Bull, J. A.
Synthesis of Sulfonimidamides from Sulfenamides via an Alkoxy-Amino-λ6 -Sulfanenitrile Intermediate.
Angewandte Chemie International Edition 2019, 58, 14303-14310
Colella, M.; Tota, A.; Großjohann, A.; Carlucci, C.; Aramini, A.; Sheikh, N. S.; Degennaro, L.; Luisi, R.
Straightforward Chemo- and Stereoselective Fluorocyclopropanation of Allylic Alcohols: Exploiting the Electrophilic Nature of the Not so Elusive Fluoroiodomethyllithium.
Chemical Communications 2019, 55, 8430
Monticelli,S.; Colella, C.; Tota, A.; Pillari, V.; Langer, T.; Holzer, W.; Degennaro, L.; Pace, V.; Luisi, R.
Modular and Chemoselective Strategy for the Direct Access to α-Fluoroepoxides and aziridines via the Addition of Fluoroiodomethyl-lithium to Carbonyl-like Compounds
Organic Letters 2018, 22, 584
Musci, P.; Colella, M.; Fanelli, F.; Altomare, A.; Pisano, L.; Carlucci, C.; Luisi, R.; Degennaro, L.
Stereo- and Enantioselective Addition of Organolithiums to 2-Oxazolinylazetidines as a Synthetic Route to 2-Acylazetidines.
Frontiers in Chemistry 2019, 7. https://doi.org/10.3389/fchem.2019.00614
De Angelis, S.; Celestini, P.; Purgatorio, R.; Degennaro, L.; Rebuzzini, G.; Luisi, R.; Carlucci, C.
Development of a continuous flow synthesis of propranolol: tackling a competitive side reaction
Journal of Flow Chemistry 2019, 9, 231-236.
De Angelis, S.; Triminì, A.; Franco, M.; Degennaro, L.; Romanazzi, G.; Carlucci, C.; González, A.; Sainz, R.; Goñi, A.; Ferritto, R.; Aceña, J. L.; Luisi, R. Belén Cid, M.
A Study of Graphene-Based Copper Catalysts: Copper(I) Nanoplatelets for Batch and Continuous-Flow Applications
Chemistry - An Asian Journal 2019, 14, 3011-3018.
Lauder, K.; Masci, D.; Toscani, A.; Al Mekdad, A.; Black, G. W.; Brown, N. L.; Turner, N. J.; Luisi, R.; Castagnolo, D.
A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution
Organic and Biomolecular Chemistry 2019, 17, 8982-8986.
Colella, M.; Musci, P.; Luisi, R.; Degennaro, L.
Synthesis and use of halodifluoromethyl heterocycles
Targets in Heterocyclic Systems, 2019; Vol. 23; pp 384-398.
Carlucci, C.; Andresini, M.; Degennaro, L.; Luisi, R.
Benchmarking acidic and basic catalysis for a robust production of biofuel from waste cooking oil.
Catalysts 2019, 9, 1050.
Carlucci, C.; Degennaro, L.; Luisi, R.
Titanium Dioxide as a Catalyst in Biodiesel Production.
Catalysts 2019, 9 (1), 75
2018
Colella, M.; Carlucci, C.; Luisi, R.
Supported Catalysts for Continuous Flow Synthesis
Topics in Current Chemistry 2018, 376, 46
Tota, A.; St John-Campbell, S.; Briggs, E. L.; Estévez, G. O.; Afonso, M.; Degennaro, L.; Luisi, R.; Bull, J. A.
Highly Chemoselective NH- and O-Transfer to Thiols Using Hypervalent Iodine Reagents: Synthesis of Sulfonimidates and Sulfonamides.
Org. Lett. 2018, 20, 2599-2602
De Angelis, Hone, C.; Degennaro, L.; Celestini, P.; Luisi, R.; Kappe, O.
Sequential α-Lithiation and Aerobic Oxidation of an Arylacetic Acid - Continuous-Flow Synthesis of Cyclopentyl Mandelic Acid
J. Flow. Chem. 2018, 8, 109–116
De Angelis, S.; Carlucci, C.; de Candia, M.; Rebuzzini, G.; Celestini, P.; Riscazzi, M.; Luisi, R.; Degennaro, L.,
Targeting a Mirabegron precursor by BH3-mediated continuous flow reduction process.
Catalysis Today 2018, 308, 81-85
Andresini, M.; De Angelis, S.; Uricchio, A.; Visaggio, A.; Romanazzi, G.; Ciriaco, F.; Corriero, N.; Degennaro, L.; Luisi, R.
Azetidine-Borane Complexes: Synthesis, Reactivity, and Stereoselective Functionalization.
J. Org. Chem. 2018, 83 (17), 10221-10230
Luisi, R.; Degennaro, L.,
Use of azetidine scaffolds in stereoselective transformations (microreview).
Chem. Heter. Comp. 2018, 54, 400-402
Carlucci, C.; Tota, A.; Colella, M.; Ronamazzi, G.; Clarkson, G. J.; Luisi, R.; Degennaro, L.
Use of Hypervalent Iodine in the Synthesis of Isomeric Dihydrooxazoles.
Chem. Heter. Comp. 2018, 54, 428-436
Colella, M.; Musci, P.; Carlucci, C.; Lillini, S.; Tomassetti, M.; Aramini, A.; Degennaro, L.; Luisi, R.
1,3-Dibromo-1,1-difluoro-2-propanone as Useful Synthon for a Chemoselective Preparation of 4-Bromodifluoromethyl Thiazoles
ACS Omega, 2018, 3, 14841–14848
2017
Parisi, G.; Colella, M.; Monticelli, S.; Romanazzi, G.; Holzer, W.; Langer, T.; Degennaro, L.; Pace, V.; Luisi, R.
Exploiting a "beast" in carbenoid chemistry: Development of a straightforward direct nucleophilic fluoromethylation strategy.
J. Am. Chem. Soc. 2017, 139, 13648-13651
Tota, A.; Zenzola, M.; Chawner, S. J.; John-Campbell, S. S.; Carlucci, C.; Romanazzi, G.; Degennaro, L.; Bull, J. A.; Luisi, R.
Synthesis of NH-sulfoximines from sulfides by chemoselective one-pot N- and O-transfers.
Chem. Commun. 2017, 53, 348-351
Parisi, G.; Degennaro, L.; Carlucci, C.; De Candia, M.; Mastrorilli, P.; Roller, A.; Holzer, W.; Altomare, C. D.; Pace, V.; Luisi, R.
A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles
Org. Biom. Chem. 2017, 15, 5000-5015
Tota, A.; Fanelli, F.; Falcicchio, A.; Luisi, R.; Degennaro, L.
Functionalization of four-membered cyclic sulfoximines by a convenient lithiation/trapping sequence
Chem. Het Comp. 2017, 53, 322-328
Romanazzi, G.; Degennaro, L.; Mastrorilli, P.; Luisi, R.
Chiral Switchable Catalysts for Dynamic Control of Enantioselectivity
ACS Catalysis 2017, 7, 4100-4114
Fanelli, F.; Parisi, G.; Degennaro, L.; Luisi, R.
Contribution of microreactor technology and flow chemistry to the development of green and sustainable synthesis
Beilstein J. Org. Chem. 2017, 13, 520-542
Degennaro, L.; Tota, A.; De Angelis, S.; Andresini, M.; Cardellicchio, C.; Capozzi, M. A.; Romanazzi, G.; Luisi, R.
A Convenient, Mild, and Green Synthesis of NH-Sulfoximines in Flow Reactors
Eur. J. Org. Chem. 2017, 6486-6490
De Angelis, S.; Celestini, P.; Rebuzzini, G.; Degennaro, L.; Luisi, R.
A Practical 11B NMR Evaluation of BH3 Titer in Commercial Solutions
Synthesis 2017, 49, 1969-1971
Bull, J. A.; Degennaro, L.; Luisi, R.
Straightforward Strategies for the Preparation of NH-Sulfox-imines: A Serendipitous Story
Synlett 2017, 28, 2525-2538
Degennaro, L.; Zenzola, M.; Laurino, A.; Cavalluzzi, M. M.; Franchini, C.; Habtemariam, S.; Matucci, R.; Luisi, R.; Lentini, G.
2-Arylazetidines as ligands for nicotinic acetylcholine receptors
Chem. Heter. Comp. 2017, 53, 329-334
Denora, N.; Lopedota, A.; de Candia, M.; Cellamare, S.; Degennaro, L.; Mele, A.; Tricarico, D.; Cutrignelli, A.; Laquintana, V.; Altomare, C. D.; Franco, M.; Dimiccoli, V.; Tolomeo, A.; Scilimati, A.; Luisi, R.
Pharmaceutical development of novel lactate-based 6-fluoro-L-DOPA formulations
Eur. J. Pharm. Sci. 2017, 99, 361-368
Antermite, D.; Degennaro, L.; Luisi, R.
Recent advances in the chemistry of metallated azetidines
Org. Biom. Chem. 2017, 15, 34-50
2016
Zenzola, M.; Doran, R.; Degennaro, L.; Luisi, R.; Bull, J. A.
Transfer of Electrophilic NH Using Convenient Sources of Ammonia: Direct Synthesis of NH Sulfoximines from Sulfoxides
Angew. Chem. Int. Ed. 2016, 55, 7203-7207
Pisano, L.; Degennaro, L.; Carraro, M.; Azzena, U.; Fanelli, F.; Mastrorilli, P.; Luisi, R.
Computational NMR as Useful Tool for Predicting Structure and Stereochemistry of Four-Membered Sulfur Heterocycles
Eur. J. Org. Chem. 2016, 2016, 3252-3258
Parisi, G.; Zenzola, M.; Capitanelli, E.; Carlucci, C.; Romanazzi, G.; Pisano, L.; Degennaro, L.; Luisi, R.
Exploiting structural and conformational effects for a site-selective lithiation of azetidines
Pure Appl. Chem. 2016, 88, 631-648
Degennaro, L.; Nagaki, A.; Moriwaki, Y.; Romanazzi, G.; Dell'anna, M. M.; Yoshida, J. I.; Luisi, R.
Flow microreactor synthesis of 2,2-disubstituted oxetanes via 2-phenyloxetan-2-yl lithium
Open Chem. 2016, 14, 377-382
Degennaro, L.; Maggiulli, D.; Carlucci, C.; Fanelli, F.; Romanazzi, G.; Luisi, R.
A direct and sustainable synthesis of tertiary butyl esters enabled by flow microreactors
Chem. Commun. 2016, 52, 9554-9557
Degennaro, L.; Carlucci, C.; De Angelis, S.; Luisi, R.
Flow technology for organometallic-mediated synthesis
J. Flow Chem. 2016, 6, 136-166
De Angelis, S.; De Renzo, M.; Carlucci, C.; Degennaro, L.; Luisi, R.
A convenient enantioselective CBS-reduction of arylketones in flow-microreactor systems
Org. Biom. Chem. 2016, 14, 4304-4311
2015
Zenzola, M.; Doran, R.; Luisi, R.; Bull, J. A.
Synthesis of Sulfoximine Carbamates by Rhodium-Catalyzed Nitrene Transfer of Carbamates to Sulfoxides
J. Org. Chem.2015, 80, 6391-6399
Parisi, G.; Capitanelli, E.; Pierro, A.; Romanazzi, G.; Clarkson, G. J.; Degennaro, L.; Luisi, R.
Easy access to constrained peptidomimetics and 2,2-disubstituted azetidines by the unexpected reactivity profile of α-lithiated N-Boc-azetidines
Chem. Commun. 2015, 51, 15588-15591
Degennaro, L.; Pisano, L.; Parisi, G.; Mansueto, R.; Clarkson, G. J.; Shipman, M.; Luisi, R.
Nitrogen Stereodynamics and Complexation Phenomena as Key Factors in the Deprotonative Dynamic Resolution of Alkylideneaziridines: A Spectroscopic and Computational Study
J. Org. Chem. 2015, 80, 6411-6418
Pati, M. L.; Abate, C.; Contino, M.; Ferorelli, S.; Luisi, R.; Carroccia, L.; Niso, M.; Berardi, F.
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate P-glycoprotein (P-gp) activity from 2 receptor affinity in mixed P-gp/σ2 receptor agents
Eur. J. Med. Chem. 2015, 89, 691-700
Degennaro, L.; Fanelli, F.; Giovine, A.; Luisi, R.
External trapping of halomethyllithium enabled by flow microreactors
Adv. Synth. Cat. 2015, 357, 21-27
Degennaro, L.; Carroccia, L.; Parisi, G.; Zenzola, M.; Romanazzi, G.; Fanelli, F.; Pisano, L.; Luisi, R.
Regio- and Stereoselective Synthesis of Sulfur-Bearing Four-Membered Heterocycles: Direct Access to 2,4-Disubstituted Thietane 1-Oxides
J. Org. Chem. 2015, 80, 12201-12211
Castagnolo, D.; Degennaro, L.; Luisi, R.; Clayden, J.
Enantioselective carbolithiation of S-alkenyl-N-aryl thiocarbamates: Kinetic and thermodynamic control
Org. Biom. Chem. 2015, 13, 2330-2340
2014
Degennaro, L.; Zenzola, M.; Trinchera, P.; Carroccia, L.; Giovine, A.; Romanazzi, G.; Falcicchio, A.; Luisi, R.
Regioselective functionalization of 2-arylazetidines: Evaluating the ortho-directing ability of the azetidinyl ring and the α-directing ability of the N-substituent
Chem. Commun. 2014, 50, 1698-1700
Zenzola, M.; Degennaro, L.; Trinchera, P.; Carroccia, L.; Giovine, A.; Romanazzi, G.; Mastrorilli, P.; Rizzi, R.; Pisano, L.; Luisi, R.
Harnessing the ortho-directing ability of the azetidine ring for the regioselective and exhaustive functionalization of arenes
Chem. Eur. J. 2014, 20, 12190-12200
Pace, V.; Luisi, R.
Expanding the synthetic portfolio of organolithiums: Direct use in catalytic cross-coupling reactions
ChemCatChem 2014, 6, 1516-1519
Mansueto, R.; Degennaro, L.; Brière, J. F.; Griffin, K.; Shipman, M.; Florio, S.; Luisi, R.
Stereocontrolled lithiation/trapping of chiral 2-alkylideneaziridines: Investigation into the role of the aziridine nitrogen stereodynamics
Org. Biom. Chem. 2014, 12, 8505-8511
Giovine, A.; Muraglia, M.; Florio, M. A.; Rosato, A.; Corbo, F.; Franchini, C.; Musio, B.; Degennaro, L.; Luisi, R.
Synthesis of functionalized arylaziridines as potential antimicrobial agents
Molecules 2014, 19, 11505-11519
Degennaro, L.; Trinchera, P.; Luisi, R.
Recent advances in the stereoselective synthesis of aziridines
Chem. Rev. 2014, 114, 7881-7929
Carroccia, L.; Degennaro, L.; Romanazzi, G.; Cuocci, C.; Pisano, L.; Luisi, R.
Straightforward access to 4-membered sulfurated heterocycles: Introducing a strategy for the single and double functionalization of thietane 1-oxide
Org. Biom. Chem. 2014, 12, 2180-2184
Capriati, V.; Florio, S.; Luisi, R.
Complexation Phenomena and Dynamics at Work in the Lithiation Reactions of Small-Ring Heterocycles: Regio- and Stereoselectivity
Eur. J. Org. Chem. 2014, 2014, 5397-5417
Azzena, U.; Carraro, M.; Meloni, C.; Murgia, I.; Pisano, L.; Pittalis, M.; Luisi, R.; Musio, B.; Degennaro, L.
Regio- and stereochemistry of Na-mediated reductive cleavage of alkyl aryl ethers
Tetrahedron Asymmetry 2014, 25, 1550-1554
2013
Tota, A.; Zenzola, M.; Chawner, S. J.; John-Campbell, S. S.; Carlucci, C.; Romanazzi, G.; Degennaro, L.; Bull, J. A.; Luisi, R.
Synthesis of NH-sulfoximines from sulfides by chemoselective one-pot N- and O-transfers.
Chem. Commun. 2017, 53, 348-351
Castagnolo, D.; Foley, D. J.; Berber, H.; Luisi, R.; Clayden, J.
Carbolithiation of S-alkenyl-N-aryl thiocarbamates: Carbanion arylation in a connective route to tertiary thiols
Org. Lett. 2013, 15, 2116-2119
Carroccia, L.; Musio, B.; Degennaro, L.; Romanazzi, G.; Luisi, R.
Microreactor-mediated organocatalysis: Towards the development of sustainable domino reactions
J. Flow Chem. 2013, 3, 29-33
2010 - 2012
Trinchera, P.; Musio, B.; Degennaro, L.; Moliterni, A.; Falcicchio, A.; Luisi, R.
One-pot preparation of piperazines by regioselective ring-opening of non-activated arylaziridines
Org. Biom. Chem. 2012, 10, 1962-1965
Degennaro, L.; Mansueto, R.; Carenza, E.; Rizzi, R.; Florio, S.; Pratt, L. M.; Luisi, R.
Nitrogen dynamics and reactivity of chiral aziridines: Generation of configurationally stable aziridinyllithium compounds
Chem. Eur. J. 2011, 17, 4992-5003
De Ceglie, M. C.; Musio, B.; Affortunato, F.; Moliterni, A.; Altomare, A.; Florio, S.; Luisi, R.
Solvent- and temperature-dependent functionalisation of enantioenriched aziridines
Chem. Eur. J. 2011, 17, 286-296
De Ceglie, M. C.; Degennaro, L.; Falcicchio, A.; Luisi, R.
Restricted rotations and stereodynamics of aziridine-2-methanol derivatives
Tetrahedron 2011, 67, 9382-9388
Azzena, U.; Dettori, G.; Pisano, L.; Musio, B.; Luisi, R.
BH3-promoted stereoselective β-lithiation of N-alkyl-2-phenylaziridines
J. Org. Chem. 2011, 76, 2291-2295
Florio, S.; Luisi, R.
Aziridinyl anions: Generation, reactivity, and use in modern synthetic chemistry
Chem. Rev. 2010, 110, 5128-5157
Luisi, R.; Giovine, A.; Florio, S.
New arylaziridinyldifluoroborates: Useful Suzuki-Miyaura reagents
Chem. Eur. J. 2010, 16, 2683-2687