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PUBLICATIONS - 2010 - 2020



Tota, A., Carlucci, C., Pisano, L., Degennaro, L., Cutolo, G., Clarkson, G., Romanazzi, G., Bull, J. A., Rollin, P., Luisi, R.

Synthesis of glycosyl sulfoximines by a highly chemo- And stereoselective NH- And O-transfer to thioglycosides

Organic and Biomolecular Chemistry 2020, 18, 3893-3897


Colella, M., Degennaro, L., Luisi, R.

Continuous flow synthesis of heterocycles: A recent update on the flow synthesis of indoles

Molecules 2020, 25, 3242 - Open Acess


   Andresini, M., Degennaro, L., Luisi, R. 

The renaissance of strained 1-azabicyclo[1.1.0]butanes as useful reagents for the synthesis of functionalized azetidines      

Organic and Biomolecular Chemistry 2020, 18, 5798-5810


 Andresini, M., Spennacchio, M., Ciriaco F.,Clarkson G. Romanazzi, G., Degennaro, L., Luisi, R.   

Synthesis of Sulfinamidines and Sulfinimidate Esters by Transfer of Nitrogen to Sulfenamides

Organic Letters 2020, 22, 7129-7134


Musci, P.; Colella, M.; Sivo, A.; Romanazzi, G.; Degennaro, L.; Luisi, R.

Flow Microreactor Technology for Taming Highly Reactive Chloroiodomethyllithium Carbenoid: Direct and Chemoselective Synthesis of α‑Chloroaldehydes

Organic Letters 2020,  doi:10.1021/acs.orglett.0c01085


Colella, M.; Tota, A.; Takahashi, Y.; Higuma, R.; Degennaro, L.; Nagaki, A.; Luisi, R

Fluoro-substituted Methyllithium Chemistry Based on A Novel External Quenching Method Using Flow Microreactors

Angew. Chem. Int. Ed. 2020, doi:10.1002/anie.202003831


Colella, M.; Nagaki, A.; Luisi, R.


Flow Technology for the Genesis and Use of (Highly) Reactive Organometallic Reagents. 

Open Access Review

Chemistry - A European Journal 2020, 26 (1), 19-32


Musio, B.;.et al.... Luisi, R.; Gallo, V.


A community-built calibration system: The case study of quantification of metabolites in grape juice by qNMR spectroscopy. 

Talanta, 214. doi:10.1016/j.talanta.2020.120855


Takahashi, Y.;  Ashikari, Y.;  Takumi, M.;  Shimizu, Y.;  Jiang, Y.;  Higuma, R.;  Ishikawa, S.;  Sakaue, H.;  Shite, I.;  Maekawa, K.;  Aizawa, Y.;  Yamashita, H.;  Yonekura, Y.;  Colella, M.;  Luisi, R.;  Takegawa, T.;  Fujita, C.; Nagaki, A.,

Synthesis of Biaryls Having a Piperidylmethyl Group Based on Space Integration of Lithiation, Borylation, and Suzuki–Miyaura Coupling. 

European Journal of Organic Chemistry 2020, 2020 (5), 618-622.



Briggs, E. L.; Tota, A.; Colella, M.; Degennaro, L.; Luisi, R.; Bull, J. A.

Synthesis of Sulfonimidamides from Sulfenamides via an Alkoxy-Amino-λ6 -Sulfanenitrile Intermediate.

Angewandte Chemie International Edition 2019, 58, 14303-14310


Colella, M.; Tota, A.; Großjohann, A.; Carlucci, C.; Aramini, A.; Sheikh, N. S.; Degennaro, L.; Luisi, R.


Straightforward Chemo- and Stereoselective Fluorocyclopropanation of Allylic Alcohols: Exploiting the Electrophilic Nature of the Not so Elusive Fluoroiodomethyllithium.

Chemical Communications 2019, 55, 8430


Monticelli,S.; Colella, C.; Tota, A.;  Pillari, V.; Langer, T.; Holzer, W.; Degennaro, L.; Pace, V.; Luisi, R.


Modular and Chemoselective Strategy for the Direct Access to α-Fluoroepoxides and aziridines via the Addition of Fluoroiodomethyl-lithium to Carbonyl-like Compounds 

Organic Letters 2018, 22, 584


Musci, P.; Colella, M.; Fanelli, F.; Altomare, A.; Pisano, L.; Carlucci, C.; Luisi, R.; Degennaro, L. 

Stereo- and Enantioselective Addition of Organolithiums to 2-Oxazolinylazetidines as a Synthetic Route to 2-Acylazetidines.

Frontiers in Chemistry 2019, 7.


De Angelis, S.; Celestini, P.; Purgatorio, R.; Degennaro, L.; Rebuzzini, G.; Luisi, R.; Carlucci, C. 


Development of a continuous flow synthesis of propranolol: tackling a competitive side reaction 

Journal of Flow Chemistry 2019, 9, 231-236.


De Angelis, S.;  Triminì, A.;  Franco, M.; Degennaro, L.; Romanazzi, G.; Carlucci, C.; González, A.; Sainz, R.;  Goñi, A.; Ferritto, R.;  Aceña, J. L.;  Luisi, R.   Belén Cid, M.

A Study of Graphene-Based Copper Catalysts: Copper(I) Nanoplatelets for Batch and Continuous-Flow Applications

Chemistry - An Asian Journal 2019, 14, 3011-3018.


Lauder, K.; Masci, D.; Toscani, A.; Al Mekdad, A.; Black, G. W.; Brown, N. L.; Turner, N. J.; Luisi, R.; Castagnolo, D. 

A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution

Organic and Biomolecular Chemistry 2019, 17, 8982-8986.


Colella, M.; Musci, P.; Luisi, R.; Degennaro, L.

Synthesis and use of halodifluoromethyl heterocycles

Targets in Heterocyclic Systems, 2019; Vol. 23; pp 384-398.


Carlucci, C.; Andresini, M.; Degennaro, L.; Luisi, R

Benchmarking acidic and basic catalysis for a robust production of biofuel from waste cooking oil. 

Catalysts 2019, 9, 1050. 


 Carlucci, C.; Degennaro, L.; Luisi, R.



Titanium Dioxide as a Catalyst in Biodiesel Production.

Catalysts 2019, 9 (1), 75



Colella, M.; Carlucci, C.; Luisi, R.


Supported Catalysts for Continuous Flow Synthesis

Topics in Current Chemistry 2018, 376, 46


Tota, A.; St John-Campbell, S.; Briggs, E. L.; Estévez, G. O.; Afonso, M.; Degennaro, L.; Luisi, R.; Bull, J. A.

Highly Chemoselective NH- and O-Transfer to Thiols Using Hypervalent Iodine Reagents: Synthesis of Sulfonimidates and Sulfonamides.

Org. Lett. 2018, 20, 2599-2602


De Angelis, Hone, C.; Degennaro, L.; Celestini, P.; Luisi, R.; Kappe, O. 

Sequential α-Lithiation and Aerobic Oxidation of an Arylacetic Acid - Continuous-Flow Synthesis of Cyclopentyl Mandelic Acid

J. Flow. Chem. 2018, 8, 109–116


De Angelis, S.; Carlucci, C.; de Candia, M.; Rebuzzini, G.; Celestini, P.; Riscazzi, M.; Luisi, R.; Degennaro, L.,


Targeting a Mirabegron precursor by BH3-mediated continuous flow reduction process.

Catalysis Today 2018, 308, 81-85


Andresini, M.; De Angelis, S.; Uricchio, A.; Visaggio, A.; Romanazzi, G.; Ciriaco, F.; Corriero, N.; Degennaro, L.; Luisi, R.


 Azetidine-Borane Complexes: Synthesis, Reactivity, and Stereoselective Functionalization.

J. Org. Chem. 2018, 83 (17), 10221-10230


Luisi, R.; Degennaro, L., 


Use of azetidine scaffolds in stereoselective transformations (microreview).

Chem. Heter. Comp. 2018, 54, 400-402


Carlucci, C.; Tota, A.; Colella, M.; Ronamazzi, G.; Clarkson, G. J.; Luisi, R.; Degennaro, L.


Use of Hypervalent Iodine in the Synthesis of Isomeric Dihydrooxazoles.

Chem. Heter. Comp. 2018, 54, 428-436


Colella, M.; Musci, P.; Carlucci, C.; Lillini, S.; Tomassetti, M.; Aramini, A.; Degennaro, L.; Luisi, R.

1,3-Dibromo-1,1-difluoro-2-propanone as Useful Synthon for a Chemoselective Preparation of  4-Bromodifluoromethyl Thiazoles

ACS Omega, 2018, 3, 14841–14848



Parisi, G.; Colella, M.; Monticelli, S.; Romanazzi, G.; Holzer, W.; Langer, T.; Degennaro, L.; Pace, V.; Luisi, R.


Exploiting a "beast" in carbenoid chemistry: Development of a straightforward direct nucleophilic fluoromethylation strategy.   

J.  Am. Chem. Soc. 2017, 139, 13648-13651


Tota, A.; Zenzola, M.; Chawner, S. J.; John-Campbell, S. S.; Carlucci, C.; Romanazzi, G.; Degennaro, L.; Bull, J. A.; Luisi, R.


Synthesis of NH-sulfoximines from sulfides by chemoselective one-pot N- and O-transfers.

Chem. Commun. 2017, 53, 348-351


Parisi, G.; Degennaro, L.; Carlucci, C.; De Candia, M.; Mastrorilli, P.; Roller, A.; Holzer, W.; Altomare, C. D.; Pace, V.; Luisi, R.

A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles 

Org. Biom. Chem. 2017, 15, 5000-5015


Tota, A.; Fanelli, F.; Falcicchio, A.; Luisi, R.; Degennaro, L.

Functionalization of four-membered cyclic sulfoximines by a convenient lithiation/trapping sequence 

Chem. Het Comp. 2017, 53, 322-328


Romanazzi, G.; Degennaro, L.; Mastrorilli, P.; Luisi, R.

Chiral Switchable Catalysts for Dynamic Control of Enantioselectivity 

ACS Catalysis 2017, 7, 4100-4114


Fanelli, F.; Parisi, G.; Degennaro, L.; Luisi, R.

Contribution of microreactor technology and flow chemistry to the development of green and sustainable synthesis 


Beilstein J. Org. Chem. 2017, 13, 520-542


Degennaro, L.; Tota, A.; De Angelis, S.; Andresini, M.; Cardellicchio, C.; Capozzi, M. A.; Romanazzi, G.; Luisi, R. 

A Convenient, Mild, and Green Synthesis of NH-Sulfoximines in Flow Reactors

Eur. J.  Org. Chem. 2017, 6486-6490


De Angelis, S.; Celestini, P.; Rebuzzini, G.; Degennaro, L.; Luisi, R.

A Practical 11B NMR Evaluation of BH3 Titer in Commercial Solutions

Synthesis 2017, 49, 1969-1971


Bull, J. A.; Degennaro, L.; Luisi, R.

Straightforward Strategies for the Preparation of NH-Sulfox-imines: A Serendipitous Story

Synlett 2017, 28, 2525-2538


Degennaro, L.; Zenzola, M.; Laurino, A.; Cavalluzzi, M. M.; Franchini, C.; Habtemariam, S.; Matucci, R.; Luisi, R.; Lentini, G. 

2-Arylazetidines as ligands for nicotinic acetylcholine receptors 

Chem. Heter. Comp. 2017, 53, 329-334


Denora, N.; Lopedota, A.; de Candia, M.; Cellamare, S.; Degennaro, L.; Mele, A.; Tricarico, D.; Cutrignelli, A.; Laquintana, V.; Altomare, C. D.; Franco, M.; Dimiccoli, V.; Tolomeo, A.; Scilimati, A.; Luisi, R.

Pharmaceutical development of novel lactate-based 6-fluoro-L-DOPA formulations

Eur. J. Pharm. Sci. 2017, 99, 361-368


Antermite, D.; Degennaro, L.; Luisi, R. 

Recent advances in the chemistry of metallated azetidines

Org. Biom. Chem. 2017, 15, 34-50



Zenzola, M.; Doran, R.; Degennaro, L.; Luisi, R.; Bull, J. A. 

Transfer of Electrophilic NH Using Convenient Sources of Ammonia: Direct Synthesis of NH Sulfoximines from Sulfoxides 

Angew. Chem. Int. Ed. 2016, 55, 7203-7207


Pisano, L.; Degennaro, L.; Carraro, M.; Azzena, U.; Fanelli, F.; Mastrorilli, P.; Luisi, R. 

Computational NMR as Useful Tool for Predicting Structure and Stereochemistry of Four-Membered Sulfur Heterocycles 

Eur. J. Org. Chem. 2016, 2016, 3252-3258


Parisi, G.; Zenzola, M.; Capitanelli, E.; Carlucci, C.; Romanazzi, G.; Pisano, L.; Degennaro, L.; Luisi, R. 

Exploiting structural and conformational effects for a site-selective lithiation of azetidines 

Pure Appl. Chem. 2016, 88, 631-648


Degennaro, L.; Nagaki, A.; Moriwaki, Y.; Romanazzi, G.; Dell'anna, M. M.; Yoshida, J. I.; Luisi, R. 

Flow microreactor synthesis of 2,2-disubstituted oxetanes via 2-phenyloxetan-2-yl lithium 

Open Chem. 2016, 14, 377-382


Degennaro, L.; Maggiulli, D.; Carlucci, C.; Fanelli, F.; Romanazzi, G.; Luisi, R. 

A direct and sustainable synthesis of tertiary butyl esters enabled by flow microreactors 

Chem. Commun. 2016, 52, 9554-9557


Degennaro, L.; Carlucci, C.; De Angelis, S.; Luisi, R.

Flow technology for organometallic-mediated synthesis

J. Flow Chem. 2016, 6, 136-166


De Angelis, S.; De Renzo, M.; Carlucci, C.; Degennaro, L.; Luisi, R. 

A convenient enantioselective CBS-reduction of arylketones in flow-microreactor systems

Org. Biom. Chem. 2016, 14, 4304-4311



Zenzola, M.; Doran, R.; Luisi, R.; Bull, J. A.

Synthesis of Sulfoximine Carbamates by Rhodium-Catalyzed Nitrene Transfer of Carbamates to Sulfoxides

J. Org. Chem.2015, 80, 6391-6399


Parisi, G.; Capitanelli, E.; Pierro, A.; Romanazzi, G.; Clarkson, G. J.; Degennaro, L.; Luisi, R. 

Easy access to constrained peptidomimetics and 2,2-disubstituted azetidines by the unexpected reactivity profile of α-lithiated N-Boc-azetidines 

Chem. Commun. 2015, 51, 15588-15591


Degennaro, L.; Pisano, L.; Parisi, G.; Mansueto, R.; Clarkson, G. J.; Shipman, M.; Luisi, R. 

Nitrogen Stereodynamics and Complexation Phenomena as Key Factors in the Deprotonative Dynamic Resolution of Alkylideneaziridines: A Spectroscopic and Computational Study 

J. Org. Chem. 2015, 80, 6411-6418


Pati, M. L.; Abate, C.; Contino, M.; Ferorelli, S.; Luisi, R.; Carroccia, L.; Niso, M.; Berardi, F. 

Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate P-glycoprotein (P-gp) activity from 2 receptor affinity in mixed P-gp/σ2 receptor agents 

Eur. J. Med. Chem. 2015, 89, 691-700


Degennaro, L.; Fanelli, F.; Giovine, A.; Luisi, R.

External trapping of halomethyllithium enabled by flow microreactors

Adv. Synth. Cat. 2015, 357, 21-27


Degennaro, L.; Carroccia, L.; Parisi, G.; Zenzola, M.; Romanazzi, G.; Fanelli, F.; Pisano, L.; Luisi, R.

Regio- and Stereoselective Synthesis of Sulfur-Bearing Four-Membered Heterocycles: Direct Access to 2,4-Disubstituted Thietane 1-Oxides

J. Org. Chem. 2015, 80, 12201-12211


Castagnolo, D.; Degennaro, L.; Luisi, R.; Clayden, J.

Enantioselective carbolithiation of S-alkenyl-N-aryl thiocarbamates: Kinetic and thermodynamic control 

Org. Biom. Chem. 2015, 13, 2330-2340



Degennaro, L.; Zenzola, M.; Trinchera, P.; Carroccia, L.; Giovine, A.; Romanazzi, G.; Falcicchio, A.; Luisi, R.

Regioselective functionalization of 2-arylazetidines: Evaluating the ortho-directing ability of the azetidinyl ring and the α-directing ability of the N-substituent 

Chem. Commun. 2014, 50, 1698-1700


Zenzola, M.; Degennaro, L.; Trinchera, P.; Carroccia, L.; Giovine, A.; Romanazzi, G.; Mastrorilli, P.; Rizzi, R.; Pisano, L.; Luisi, R.

Harnessing the ortho-directing ability of the azetidine ring for the regioselective and exhaustive functionalization of arenes 

Chem. Eur. J. 2014, 20, 12190-12200


Pace, V.; Luisi, R. 

Expanding the synthetic portfolio of organolithiums: Direct use in catalytic cross-coupling reactions

ChemCatChem 2014, 6, 1516-1519


Mansueto, R.; Degennaro, L.; Brière, J. F.; Griffin, K.; Shipman, M.; Florio, S.; Luisi, R.

Stereocontrolled lithiation/trapping of chiral 2-alkylideneaziridines: Investigation into the role of the aziridine nitrogen stereodynamics

Org. Biom. Chem. 2014, 12, 8505-8511


Giovine, A.; Muraglia, M.; Florio, M. A.; Rosato, A.; Corbo, F.; Franchini, C.; Musio, B.; Degennaro, L.; Luisi, R.

Synthesis of functionalized arylaziridines as potential antimicrobial agents

Molecules 2014, 19, 11505-11519


Degennaro, L.; Trinchera, P.; Luisi, R.

Recent advances in the stereoselective synthesis of aziridines

Chem. Rev. 2014, 114, 7881-7929


Carroccia, L.; Degennaro, L.; Romanazzi, G.; Cuocci, C.; Pisano, L.; Luisi, R. 

Straightforward access to 4-membered sulfurated heterocycles: Introducing a strategy for the single and double functionalization of thietane 1-oxide

Org. Biom. Chem. 2014, 12, 2180-2184


Capriati, V.; Florio, S.; Luisi, R.

Complexation Phenomena and Dynamics at Work in the Lithiation Reactions of Small-Ring Heterocycles: Regio- and Stereoselectivity

Eur. J. Org. Chem. 2014, 2014, 5397-5417


Azzena, U.; Carraro, M.; Meloni, C.; Murgia, I.; Pisano, L.; Pittalis, M.; Luisi, R.; Musio, B.; Degennaro, L.

Regio- and stereochemistry of Na-mediated reductive cleavage of alkyl aryl ethers

Tetrahedron Asymmetry 2014, 25, 1550-1554



Tota, A.; Zenzola, M.; Chawner, S. J.; John-Campbell, S. S.; Carlucci, C.; Romanazzi, G.; Degennaro, L.; Bull, J. A.; Luisi, R.


Synthesis of NH-sulfoximines from sulfides by chemoselective one-pot N- and O-transfers.

Chem. Commun. 2017, 53, 348-351


Castagnolo, D.; Foley, D. J.; Berber, H.; Luisi, R.; Clayden, J. 

Carbolithiation of S-alkenyl-N-aryl thiocarbamates: Carbanion arylation in a connective route to tertiary thiols 

Org. Lett. 2013, 15, 2116-2119


Carroccia, L.; Musio, B.; Degennaro, L.; Romanazzi, G.; Luisi, R.

Microreactor-mediated organocatalysis: Towards the development of sustainable domino reactions

J. Flow Chem. 2013, 3, 29-33

2010 - 2012


Trinchera, P.; Musio, B.; Degennaro, L.; Moliterni, A.; Falcicchio, A.; Luisi, R.

One-pot preparation of piperazines by regioselective ring-opening of non-activated arylaziridines

Org. Biom. Chem. 2012, 10, 1962-1965


Degennaro, L.; Mansueto, R.; Carenza, E.; Rizzi, R.; Florio, S.; Pratt, L. M.; Luisi, R.

Nitrogen dynamics and reactivity of chiral aziridines: Generation of configurationally stable aziridinyllithium compounds


Chem. Eur. J. 2011, 17, 4992-5003


De Ceglie, M. C.; Musio, B.; Affortunato, F.; Moliterni, A.; Altomare, A.; Florio, S.; Luisi, R.

Solvent- and temperature-dependent functionalisation of enantioenriched aziridines

Chem. Eur. J. 2011, 17, 286-296


De Ceglie, M. C.; Degennaro, L.; Falcicchio, A.; Luisi, R.

Restricted rotations and stereodynamics of aziridine-2-methanol derivatives

Tetrahedron 2011, 67, 9382-9388


Azzena, U.; Dettori, G.; Pisano, L.; Musio, B.; Luisi, R. 

BH3-promoted stereoselective β-lithiation of N-alkyl-2-phenylaziridines

J. Org. Chem. 2011, 76, 2291-2295


Florio, S.; Luisi, R.

Aziridinyl anions: Generation, reactivity, and use in modern synthetic chemistry 

Chem. Rev. 2010, 110, 5128-5157


Luisi, R.; Giovine, A.; Florio, S.

New arylaziridinyldifluoroborates: Useful Suzuki-Miyaura reagents

Chem. Eur. J. 2010, 16, 2683-2687

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